Abstract
Iron is the most abundant chemical element on Earth but its most common oxidation state is Fe(III) which presents a very low solubility under physiological conditions. During evolution, micro-organisms have developed sound strategies to acquire iron from both the environment and superior organisms, including direct uptake of iron ions from exogenous iron/heme sources and the synthesis of specialized Fe(III) chelators called siderophores. The present review paper aims at presenting and discussing the latest achievements in siderophore isolation and production, as well as novel applications of these molecules in therapies against iron-related diseases and in vaccines, and their application as antimicrobial agents and biosensors.
Keywords: Antibacteria, antifungal, antimicrobial, biosensor, catecholate, chelation therapy, hydroxamate, iron chelation, iron homeostasis, iron overload, Neurodegenerative diseases, Pathogen competition, Pyoverdin, Siderophore, synthesis, vaccines
Recent Patents on Biotechnology
Title: Recent Achievements on Siderophore Production and Application
Volume: 5 Issue: 3
Author(s): Carla C.C.R. de Carvalho, Marco P.C. Marques and Pedro Fernandes
Affiliation:
Keywords: Antibacteria, antifungal, antimicrobial, biosensor, catecholate, chelation therapy, hydroxamate, iron chelation, iron homeostasis, iron overload, Neurodegenerative diseases, Pathogen competition, Pyoverdin, Siderophore, synthesis, vaccines
Abstract: Iron is the most abundant chemical element on Earth but its most common oxidation state is Fe(III) which presents a very low solubility under physiological conditions. During evolution, micro-organisms have developed sound strategies to acquire iron from both the environment and superior organisms, including direct uptake of iron ions from exogenous iron/heme sources and the synthesis of specialized Fe(III) chelators called siderophores. The present review paper aims at presenting and discussing the latest achievements in siderophore isolation and production, as well as novel applications of these molecules in therapies against iron-related diseases and in vaccines, and their application as antimicrobial agents and biosensors.
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Cite this article as:
C.C.R. de Carvalho Carla, P.C. Marques Marco and Fernandes Pedro, Recent Achievements on Siderophore Production and Application, Recent Patents on Biotechnology 2011; 5 (3) . https://dx.doi.org/10.2174/187220811797579114
DOI https://dx.doi.org/10.2174/187220811797579114 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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