Abstract
RNA silencing negatively regulates gene expression at transcriptional and posttranscriptional levels, guided by small RNA molecules. It modulates core regulatory pathways across the eukaryotes, such as developmental processes or stress responses. The widespread existence of this phenomenon and the key pathways regulated have led to the development of a new technology based on the modification of gene expression, which has been applied successfully in different areas such as medicine or agriculture. Here we review the most important patents related to RNA silencing across the life kingdoms, including biotechnological applications into medicine, crop science and bioengineering.
Keywords: Chlamydomonas, disease therapy, fungi, gene therapy, microRNA, patent, plant biotechnology, RNA silencing, sRNA, post-transcriptional gene silencing in plants, lymphoblastic leukaemia, anti-miRNA oligonucleotides (AMOs), Kaposi, ’, s sarcoma-associated herpesvirus (KSHV), respiratory syncytial virus (RSV), parainfluenza virus (PIV)
Recent Patents on Biotechnology
Title: Bioengineering RNA Silencing Across the Life Kingdoms
Volume: 5 Issue: 2
Author(s): R. Alvarez-Fernandez, S. Lopez-Gomollon, A. F. Lopez-Martinez and F. E. Nicolas
Affiliation:
Keywords: Chlamydomonas, disease therapy, fungi, gene therapy, microRNA, patent, plant biotechnology, RNA silencing, sRNA, post-transcriptional gene silencing in plants, lymphoblastic leukaemia, anti-miRNA oligonucleotides (AMOs), Kaposi, ’, s sarcoma-associated herpesvirus (KSHV), respiratory syncytial virus (RSV), parainfluenza virus (PIV)
Abstract: RNA silencing negatively regulates gene expression at transcriptional and posttranscriptional levels, guided by small RNA molecules. It modulates core regulatory pathways across the eukaryotes, such as developmental processes or stress responses. The widespread existence of this phenomenon and the key pathways regulated have led to the development of a new technology based on the modification of gene expression, which has been applied successfully in different areas such as medicine or agriculture. Here we review the most important patents related to RNA silencing across the life kingdoms, including biotechnological applications into medicine, crop science and bioengineering.
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Cite this article as:
Alvarez-Fernandez R., Lopez-Gomollon S., F. Lopez-Martinez A. and E. Nicolas F., Bioengineering RNA Silencing Across the Life Kingdoms, Recent Patents on Biotechnology 2011; 5 (2) . https://dx.doi.org/10.2174/187220811796365680
DOI https://dx.doi.org/10.2174/187220811796365680 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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