Abstract
Considerable research indicates that many cells of the asthmatic airway become dysfunctional. There is clear evidence for epithelial and airway smooth muscle cell dysfunction, accumulation of activated T cells, and systemic inflammation effects on peripheral blood granulocytes. A number of studies of airway cells have applied proteomics, resulting in mapped protein profiles of inflammatory cells and increased understanding of potential mechanisms involved in allergic inflammation. The reports described in this review offer many encouraging leads for further detailed analysis of allergic processes. The elucidation of their role in asthma will require the application of novel technologies and insightful biochemical interpretation. There is considerable optimism that comparative proteomic investigation of airway inflammatory cells may provide critical insights into the phenotypes of asthma and will reveal novel mechanistic targets for therapeutic interventions.
Keywords: Cellular proteomics, allergic asthma, airway inflammation, eosinophil, Late allergic reaction, Major histocompability complex, Mass spectrometry, Tumor Necrosis Factor, Vascular cell adhesion molecule, Interleukin, Interferon
Current Proteomics
Title: Proteomics of Airway Inflammatory Cells in Asthma Research
Volume: 8 Issue: 2
Author(s): Konrad Pazdrak
Affiliation:
Keywords: Cellular proteomics, allergic asthma, airway inflammation, eosinophil, Late allergic reaction, Major histocompability complex, Mass spectrometry, Tumor Necrosis Factor, Vascular cell adhesion molecule, Interleukin, Interferon
Abstract: Considerable research indicates that many cells of the asthmatic airway become dysfunctional. There is clear evidence for epithelial and airway smooth muscle cell dysfunction, accumulation of activated T cells, and systemic inflammation effects on peripheral blood granulocytes. A number of studies of airway cells have applied proteomics, resulting in mapped protein profiles of inflammatory cells and increased understanding of potential mechanisms involved in allergic inflammation. The reports described in this review offer many encouraging leads for further detailed analysis of allergic processes. The elucidation of their role in asthma will require the application of novel technologies and insightful biochemical interpretation. There is considerable optimism that comparative proteomic investigation of airway inflammatory cells may provide critical insights into the phenotypes of asthma and will reveal novel mechanistic targets for therapeutic interventions.
Export Options
About this article
Cite this article as:
Pazdrak Konrad, Proteomics of Airway Inflammatory Cells in Asthma Research, Current Proteomics 2011; 8 (2) . https://dx.doi.org/10.2174/157016411795678011
DOI https://dx.doi.org/10.2174/157016411795678011 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Regulatory Role of the α7nAChR in Cancer
Current Drug Targets Aerosol Performance of Large Respirable Particles of Amikacin Sulfate Produced by Spray and Freeze Drying Techniques
Current Drug Delivery Host Genomics Plasticity in Response to Ambient Temperature Change: Transcriptional Regulation Induced by Cold Temperature Perception in the Human BEAS-2B Cell Line
Current Pharmacogenomics and Personalized Medicine CCR2 Antagonists
Current Topics in Medicinal Chemistry Editorial [Hot topic: Novel Approaches to Pharmacogenomic Investigations (Executive Editor: Kelan G. Tantisira)]
Current Pharmaceutical Design Editorial : (Thematic issue: Critical Appraisal of Ischemic Stroke Pathophysiology: Road to Cerebral Resuscitation? Part II)
Current Medicinal Chemistry Can Nutrition Play a Role as a Stimulant for COVID 19 in Children?
Reviews on Recent Clinical Trials Targeting Trypanosoma cruzi Platelet-activating Factor Receptors: Scope for the Development of Novel Drugs to Treat Chagas Disease
Mini-Reviews in Medicinal Chemistry Computational Studies of Budesonide vs. Vilanterol: Asthma Drugs Against SARS-CoV-2 M<sup>pro</sup>
Current Chinese Science Airway Clearance of Apoptotic Cells in COPD
Current Drug Targets Nutritional Aspects Relating to the Developmental Origins of Health and Disease
Current Women`s Health Reviews Ocular Toxocariasis: New Diagnostic and Therapeutic Perspectives
Recent Patents on Anti-Infective Drug Discovery Platelet-Derived Growth Factors (PDGFs) are Key Players in the Stimulation of Airway Smooth Muscle Cells (ASMCs) Alteration in Asthma and Chronic Obstructive Pulmonary Disease (COPD) with Multifarious Inhibitors at an Early Stage of Development
Current Proteomics Application of Functional Genomics to Bronchial Asthma
Current Pharmacogenomics Editorial [Hot Topic: Molecular Pathogenesis of Airway Diseases (Guest Editor: Devendra K. Agrawal)]
Current Molecular Medicine Update on the Cardiac Safety of Moxifloxacin
Current Drug Safety Inhibition of Leukotriene Biosynthesis by Secondary Plant Metabolites
Current Organic Chemistry Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Current Drug Targets The Role of STATs in Inflammation and Inflammatory Diseases
Current Pharmaceutical Design Resolution of Empyema Thoracis after Patient Refusal of Surgical Intervention: A Case Series and Review of the Literature
Current Respiratory Medicine Reviews