Abstract
Considerable research indicates that many cells of the asthmatic airway become dysfunctional. There is clear evidence for epithelial and airway smooth muscle cell dysfunction, accumulation of activated T cells, and systemic inflammation effects on peripheral blood granulocytes. A number of studies of airway cells have applied proteomics, resulting in mapped protein profiles of inflammatory cells and increased understanding of potential mechanisms involved in allergic inflammation. The reports described in this review offer many encouraging leads for further detailed analysis of allergic processes. The elucidation of their role in asthma will require the application of novel technologies and insightful biochemical interpretation. There is considerable optimism that comparative proteomic investigation of airway inflammatory cells may provide critical insights into the phenotypes of asthma and will reveal novel mechanistic targets for therapeutic interventions.
Keywords: Cellular proteomics, allergic asthma, airway inflammation, eosinophil, Late allergic reaction, Major histocompability complex, Mass spectrometry, Tumor Necrosis Factor, Vascular cell adhesion molecule, Interleukin, Interferon
Current Proteomics
Title: Proteomics of Airway Inflammatory Cells in Asthma Research
Volume: 8 Issue: 2
Author(s): Konrad Pazdrak
Affiliation:
Keywords: Cellular proteomics, allergic asthma, airway inflammation, eosinophil, Late allergic reaction, Major histocompability complex, Mass spectrometry, Tumor Necrosis Factor, Vascular cell adhesion molecule, Interleukin, Interferon
Abstract: Considerable research indicates that many cells of the asthmatic airway become dysfunctional. There is clear evidence for epithelial and airway smooth muscle cell dysfunction, accumulation of activated T cells, and systemic inflammation effects on peripheral blood granulocytes. A number of studies of airway cells have applied proteomics, resulting in mapped protein profiles of inflammatory cells and increased understanding of potential mechanisms involved in allergic inflammation. The reports described in this review offer many encouraging leads for further detailed analysis of allergic processes. The elucidation of their role in asthma will require the application of novel technologies and insightful biochemical interpretation. There is considerable optimism that comparative proteomic investigation of airway inflammatory cells may provide critical insights into the phenotypes of asthma and will reveal novel mechanistic targets for therapeutic interventions.
Export Options
About this article
Cite this article as:
Pazdrak Konrad, Proteomics of Airway Inflammatory Cells in Asthma Research, Current Proteomics 2011; 8 (2) . https://dx.doi.org/10.2174/157016411795678011
DOI https://dx.doi.org/10.2174/157016411795678011 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pharmacotherapy & Surgical Interventions Available for Obesity Management and Importance of Pancreatic Lipase Inhibitory Phytomolecules as Safer Anti-Obesity Therapeutics
Mini-Reviews in Medicinal Chemistry Recent Development of Drug Delivery Systems for the Treatment of Asthma and Related Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Acute Human Toxicity of Macrocyclic Lactones
Current Pharmaceutical Biotechnology Impact on Pharmaceutical Industry due to Sudden Pandemic Attack (COVID-19)
Coronaviruses The Role of Cytokines in Atopic Asthma
Current Medicinal Chemistry Mining for Protein Kinase Substrates: Integration of Biochemistry, Genetics and Proteomics
Current Proteomics Medical Management and Risk Reduction of the Cardiovascular Effects of Underwater Diving
Current Vascular Pharmacology Homocysteine and Folate Therapy in Dialysis Patients
Letters in Drug Design & Discovery Effect of Some Triterpene Glycosides Applied in vitro on Chromatin State in Human Cells
Current Bioactive Compounds Dietary Nutrients in Relation to Chronic Obstructive Pulmonary Disease: Emerging Epidemiological Evidence
Current Respiratory Medicine Reviews The Neurobiological Bases for the Pharmacotherapy of Nicotine Addiction
Current Pharmaceutical Design The Use of Microarrays to Characterize Neuropsychiatric Disorders: Postmortem Studies of Substance Abuse and Schizophrenia
Current Molecular Medicine Drug Delivery Systems with Modified Release for Systemic and Biophase Bioavailability
Current Clinical Pharmacology Controlled Release Inhalable Polymeric Microspheres for Treatment of Pulmonary Arterial Hypertension
Current Pharmaceutical Design Preclinical Models of Graves’ Disease and Associated Secondary Complications
Current Pharmaceutical Design Home Environmental Control for Children with Asthma
Current Pediatric Reviews Docking and Virtual Screening to Identify PKC Agonists: Potentials in Anticancer Therapeutics
Current Computer-Aided Drug Design Substance P: Structure, Function, and Therapeutics
Current Topics in Medicinal Chemistry Editorial [Hot Topic Advantages and Disadvantages of Inhaled Corticosteroids in the Treatment of Pulmonary Diseases Guest Editor: Nazan Cobanoglu]
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Interaction of Small Molecules with Specific Immune Receptors: The p-i Concept and its Consequences
Current Immunology Reviews (Discontinued)