Abstract
Molecular imaging via Single Photon Emission Computed Tomography (SPECT) holds considerable promise for analysis of metabolism and bio-distribution of drugs in addition to imaging of diseased states. While the related Positron Emission Tomography (PET) imaging offers higher resolution images, SPECT is considered the more practical approach to nuclear imaging for routine diagnostic use. One of the attractive features of SPECT is its utilization of medium to long-lived radioisotopes, particularly radio-iodinated species. This mini-review will survey recent advances in radioiodination, including synthetic chemistry and post-labeling purification methods.
Keywords: SPECT, radiochemistry, radioiodination, radiolabeling, radioisotopes, halodestannylation, halodethallation, fluorous labelling
Current Radiopharmaceuticals
Title: Radio-Iodination Methods for the Production of SPECT Imaging Agents
Volume: 3 Issue: 1
Author(s): K. M. Wager and G. B. Jones
Affiliation:
Keywords: SPECT, radiochemistry, radioiodination, radiolabeling, radioisotopes, halodestannylation, halodethallation, fluorous labelling
Abstract: Molecular imaging via Single Photon Emission Computed Tomography (SPECT) holds considerable promise for analysis of metabolism and bio-distribution of drugs in addition to imaging of diseased states. While the related Positron Emission Tomography (PET) imaging offers higher resolution images, SPECT is considered the more practical approach to nuclear imaging for routine diagnostic use. One of the attractive features of SPECT is its utilization of medium to long-lived radioisotopes, particularly radio-iodinated species. This mini-review will survey recent advances in radioiodination, including synthetic chemistry and post-labeling purification methods.
Export Options
About this article
Cite this article as:
Wager K. M. and Jones G. B., Radio-Iodination Methods for the Production of SPECT Imaging Agents, Current Radiopharmaceuticals 2010; 3 (1) . https://dx.doi.org/10.2174/1874471011003010037
DOI https://dx.doi.org/10.2174/1874471011003010037 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chemoradiotherapy of Human Tumors: Novel Approaches from Nanomedicine
Current Pharmaceutical Design High Frequency of the Opioid Receptor µ-1 (OPRM1) A118G Polymorphism, an Opioid Drug Therapy Related Gene, in the Indonesian Population
Current Pharmacogenomics and Personalized Medicine Noxa: Role in Cancer Pathogenesis and Treatment
Current Cancer Drug Targets T Cell Costimulatory and Inhibitory Receptors as Therapeutic Targets for Inducing Anti-Tumor Immunity
Current Cancer Drug Targets DNA Demethylation by TET Proteins: A Potential Therapeutic Target in Cancer
Epigenetic Diagnosis & Therapy (Discontinued) Inhibition of Melanogenesis by Some Well-Known Polyphenolics: A Review
Current Pharmaceutical Biotechnology Trophoblast Invasion: A Possible Link Between Implantation Deficiencies and Preeclampsia
Current Women`s Health Reviews Correlating Low-Similarity Peptide Sequences and Allergenic Epitopes
Current Pharmaceutical Design Vitamin D Insufficiency and Diabetes Risks
Current Drug Targets FoxQ1 is a Novel Molecular Target for Pancreatic Cancer and is Associated with Poor Prognosis
Current Molecular Medicine Therapeutic Targets for Metastatic Prostate Cancer
Current Drug Targets Toll-Like Receptors and their Role in Hematologic Malignancies
Current Molecular Medicine Emerging Roles of P2X Receptors in Cancer
Current Medicinal Chemistry Glycosidated Phospholipids – a Promising Group of Anti-Tumour Lipids
Anti-Cancer Agents in Medicinal Chemistry Bringing Light into the Diagnosis of Skin Disorders - Short Review on Laser Induced Fluorescence Spectroscopy and Optical Coherence Tomography in Dermatology
Current Medical Imaging Novel and Emerging Targeted Therapies of Colorectal Cancer
Current Clinical Pharmacology The DNA-Binding and Bioactivity of Rare Earth Metal Complexes
Mini-Reviews in Medicinal Chemistry Fusogenic Oncolytic Herpes Simplex Viruses as a Potent and Personalized Cancer Vaccine
Current Pharmaceutical Biotechnology Advances in Development of Inhibitors of 17β-Hydroxysteroid Dehydrogenases
Anti-Cancer Agents in Medicinal Chemistry ZIP4 is a Novel Diagnostic and Prognostic Marker in Human Pancreatic Cancer: A Systemic Comparison Between EUS-FNA and Surgical Specimens
Current Molecular Medicine