Alzheimers Disease, Ceramide, Visfatin and NAD

James   D.   Adams Jr.

Abstract

This review discusses new mechanisms for the induction of Alzheimers disease, involving lipid toxicity and adipokines. Ceramide induces oxidative stress and the formation of amyloidβ. Visfatin induces oxidative stress, damages the blood brain barrier and increases the attraction of monocytes, neutrophils and other white blood cells. A new mechanism for visfatin/NAD (nicotinamide adenine dinucleotide)-induced oxidative stress is presented involving redox cycling catalyzed by xanthine dehydrogenase and NADH oxidase. These mechanisms are discussed in terms of the treatment of Alzheimers disease.

Keywords: Alzheimer' disease, ceramide, visfatin, NAD, oxidative stress