Abstract
Increasing evidence demonstrated that Propionibacterium acnes (P. acnes) plays a central role in many human polymicrobial diseases including acne vulgaris, which afflicts more than one million people in the U.S. alone. To date, there are no appropriate therapeutic modalities that effectively control P. acnes succession during disease development. By taking advantage of the availability of genome and proteome of P. acnes, we have highlighted here the events of P. acnes adhesion and biofilm formation as potential targets for development of drugs or vaccines counteracting P. acnesassociated diseases.
Keywords: Propionibacterium acnes, acne, vaccine, lipase, biofilm, bacterial adhesion
Current Proteomics
Title: Potential Targets of P. acnes for New Treatments of P. acnes-Associated Diseases
Volume: 4 Issue: 3
Author(s): Teruaki Nakatsuji and Chun-Ming Huang
Affiliation:
Keywords: Propionibacterium acnes, acne, vaccine, lipase, biofilm, bacterial adhesion
Abstract: Increasing evidence demonstrated that Propionibacterium acnes (P. acnes) plays a central role in many human polymicrobial diseases including acne vulgaris, which afflicts more than one million people in the U.S. alone. To date, there are no appropriate therapeutic modalities that effectively control P. acnes succession during disease development. By taking advantage of the availability of genome and proteome of P. acnes, we have highlighted here the events of P. acnes adhesion and biofilm formation as potential targets for development of drugs or vaccines counteracting P. acnesassociated diseases.
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Cite this article as:
Nakatsuji Teruaki and Huang Chun-Ming, Potential Targets of P. acnes for New Treatments of P. acnes-Associated Diseases, Current Proteomics 2007; 4 (3) . https://dx.doi.org/10.2174/157016407783221295
DOI https://dx.doi.org/10.2174/157016407783221295 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
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