Abstract
Chemokines are members of a superfamily of small, cytokine-like, chemotactic proteins that have recently been shown to critically regulate leukocyte trafficking. Accumulating evidence indicates that the chronically relapsing inflammatory skin disease psoriasis represents a T cell-mediated disease. Thus, the understanding of the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics. Here results of recent studies associating chemokines with a psoriatic phenotype and delineating their role in the recruitment of memory T cells to the skin are discussed.
Keywords: chemokines, chemokine receptors, psoriasis, therapy, ccr4, ccr6, cccr10, cxcr3
Current Drug Targets - Inflammation & Allergy
Title: Chemokines and Chemokine Receptors as Targets in the Therapy of Psoriasis
Volume: 3 Issue: 2
Author(s): Bernhard Homey
Affiliation:
Keywords: chemokines, chemokine receptors, psoriasis, therapy, ccr4, ccr6, cccr10, cxcr3
Abstract: Chemokines are members of a superfamily of small, cytokine-like, chemotactic proteins that have recently been shown to critically regulate leukocyte trafficking. Accumulating evidence indicates that the chronically relapsing inflammatory skin disease psoriasis represents a T cell-mediated disease. Thus, the understanding of the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics. Here results of recent studies associating chemokines with a psoriatic phenotype and delineating their role in the recruitment of memory T cells to the skin are discussed.
Export Options
About this article
Cite this article as:
Homey Bernhard, Chemokines and Chemokine Receptors as Targets in the Therapy of Psoriasis, Current Drug Targets - Inflammation & Allergy 2004; 3 (2) . https://dx.doi.org/10.2174/1568010043343840
DOI https://dx.doi.org/10.2174/1568010043343840 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
Related Articles
-
Inhibition of Tumor Angiogenesis by Antibodies, Synthetic Small Molecules and Natural Products
Current Medicinal Chemistry Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches
Current Medicinal Chemistry Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Emerging Immunosuppressive Drugs in Kidney Transplantation
Current Clinical Pharmacology Nanofibers: New Insights for Drug Delivery and Tissue Engineering
Current Topics in Medicinal Chemistry Phytomedicines are Efficient Complementary Therapies for the Treatment of Atopic Dermatitis: A Review of Mechanistic Insight and Recent Updates
Current Drug Targets Rheumatic Heart Disease: Pathogenesis and Vaccine
Current Protein & Peptide Science Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases
Current Topics in Medicinal Chemistry Lipid Nanoparticles as Carriers for the Treatment of Neurodegeneration Associated with Alzheimer’s Disease and Glaucoma: Present and Future Challenges
Current Pharmaceutical Design Microarray Studies in Understanding the Mechanism of Action of Antiepileptic Drugs
Current Psychopharmacology Vulnerable Plaque and Inflammation: Potential Clinical Strategies
Current Pharmaceutical Design Preface [Hot topic: Insulin Resistance and Impaired Coronary Endothelial Function (Guest Editor: Teruo Inoue)]
Current Drug Targets - Cardiovascular & Hematological Disorders Effectiveness of Two Novel Anionic and Cationic Platinum Complexes in the Treatment of Osteosarcoma
Anti-Cancer Agents in Medicinal Chemistry Fenofibrate Increases Heme Oxygenase 1 Expression and Astrocyte Proliferation While Limits Neuronal Injury During Intracerebral Hemorrhage
Current Neurovascular Research subject Index To Volume 2
Current Molecular Medicine Reduction in Ischemic Cerebral Infarction is Mediated through Golgi Phosphoprotein 3 and Akt/mTOR Signaling Following Salvianolate Administration
Current Neurovascular Research Giant Cell Arteritis (GCA): Pathogenesis, Clinical Aspects and Treatment Approaches
Current Rheumatology Reviews Glycation and Hypoxia: Two Key Factors for Adipose Tissue Dysfunction
Current Medicinal Chemistry Idiosyncratic Drug Hepatotoxicity: Strategy for Prevention and Proposed Mechanism
Current Medicinal Chemistry A Simple and Rapid Method for Expression and Purification of Functional TNF-α Using GST Fusion System
Current Pharmaceutical Biotechnology