Abstract
Nitrosative stress and nitration of proteins in airway epithelium maybe responsible for steroid resistance in asthma and steroid ineffectiveness in chronic obstructive pulmonary disease (COPD), supporting the potential role of future therapeutic strategies aimed at regulating NO synthesis in asthma and COPD (for example, combination treatment with NOS inhibitors and corticosteroids). Here, the potential role of NO modulators (NO synthase inhibitors and NO donors) has been reviewed, which if are given on a regular basis may have clinical benefit in asthma and COPD.
Keywords: nitric oxide synthase, nitrotyrosine, exhaled breath condensate, exhaled nitric oxide, s-nitrosylation, l-arginine
Current Drug Targets - Inflammation & Allergy
Title: NOS: Molecular Mechanisms, Clinical Aspects, Therapeutic and Monitoring Approaches
Volume: 4 Issue: 2
Author(s): Sergei A. Kharitonov
Affiliation:
Keywords: nitric oxide synthase, nitrotyrosine, exhaled breath condensate, exhaled nitric oxide, s-nitrosylation, l-arginine
Abstract: Nitrosative stress and nitration of proteins in airway epithelium maybe responsible for steroid resistance in asthma and steroid ineffectiveness in chronic obstructive pulmonary disease (COPD), supporting the potential role of future therapeutic strategies aimed at regulating NO synthesis in asthma and COPD (for example, combination treatment with NOS inhibitors and corticosteroids). Here, the potential role of NO modulators (NO synthase inhibitors and NO donors) has been reviewed, which if are given on a regular basis may have clinical benefit in asthma and COPD.
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Cite this article as:
Kharitonov A. Sergei, NOS: Molecular Mechanisms, Clinical Aspects, Therapeutic and Monitoring Approaches, Current Drug Targets - Inflammation & Allergy 2005; 4 (2) . https://dx.doi.org/10.2174/1568010053586282
DOI https://dx.doi.org/10.2174/1568010053586282 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
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