B Cell Tolerance: Lessons from Transplantation

Marilia      Cascalho

Abstract

Given the ability of the B cell compartment to acquire tolerance to self we cannot explain why spontaneous humoral tolerance does not arise following transplantation. Here we review the fundamental mechanisms of B cell tolerance that operate in development and direct the reader to possible mechanisms that may explain how B cell tolerance fails to develop following transplantation

Keywords: b cells, antibodies, tolerance, allotransplantation

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