Abstract
Signal transduction through reversible protein phosphorylation plays a central role in cellular physiology in both normal and disease states, and mass spectrometry is well-suited to the task of identifying and cataloging protein phosphorylation sites. Recent advances in sample enrichment strategies, instrumentation, and software availability allow researchers to identify hundreds of phosphorylation sites in a single study. However, to take the next step toward translating these findings into clinical application, the biological relevance of the sites must be validated and clinical assays must be developed to monitor phospho-specific biomarkers.
Keywords: Phosphoproteomics, biomarker discovery, mass spectrometry, Phosflow™
Current Proteomics
Title: Phosphoproteomics: Challenges and Opportunities
Volume: 3 Issue: 4
Author(s): Kimberly A. Lee, Gary D. Means and Scott D. Patterson
Affiliation:
Keywords: Phosphoproteomics, biomarker discovery, mass spectrometry, Phosflow™
Abstract: Signal transduction through reversible protein phosphorylation plays a central role in cellular physiology in both normal and disease states, and mass spectrometry is well-suited to the task of identifying and cataloging protein phosphorylation sites. Recent advances in sample enrichment strategies, instrumentation, and software availability allow researchers to identify hundreds of phosphorylation sites in a single study. However, to take the next step toward translating these findings into clinical application, the biological relevance of the sites must be validated and clinical assays must be developed to monitor phospho-specific biomarkers.
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Cite this article as:
Lee A. Kimberly, Means D. Gary and Patterson D. Scott, Phosphoproteomics: Challenges and Opportunities, Current Proteomics 2006; 3 (4) . https://dx.doi.org/10.2174/157016406780655559
DOI https://dx.doi.org/10.2174/157016406780655559 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
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