Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine

Title: Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine

Volume: 1 Issue: 2

Author(s): K. A. Rittenbach and G. B. Baker

Affiliation:

Keywords: amphetamine, CYP2B6, propargylamphetamine, cDNA, Metabolism

Abstract: The metabolism of (-)-deprenyl (N-methyl,N-propargylamphetamine) and N-methyl,N-propargylphenylethylamine (MPPE), monoamine oxidase inhibitors with neuroprotective properties, was studied using human liver microsomes and cDNA-expressed cytochrome P450 (CYP) enzymes. The metabolic pathways of MPPE parallel those of (-)- deprenyl, but some marked differences were observed, particularly with regard to the contributions of CYP2B6 and CYP2D6.

Cite this article as:

Rittenbach A. K. and Baker B. G., Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine, Drug Metabolism Letters 2007; 1 (2) . https://dx.doi.org/10.2174/187231207780363589