Abstract
Sleep is characterized by synchronized electrical activities of the thalamocortical network, which can be identified as the EEG oscillations during sleep. T-type calcium channels have been implicated in the occurrence of sleep waves, and burst firings in the thalamic neurons driven by these channels are known to be essential for modulation of sleep rhythms. Studies showed that α1G T-type calcium channel knockout mice had defects in sleep waves such as lack of delta oscillations (1-4 Hz) and alteration of sleep spindles (7-15 Hz), which are known to be modulated by T-currents in the thalamus. The mutation also affected the sleep-wake transition, thus resulting in decreased NREM sleep and increased sleep disturbance. These findings support the idea that α1G T-type calcium channels contribute to sleep waves as well as to behavioral state of sleep.
Keywords: EEG oscillations, Inhibitory postsynaptic potential, Electromyogram, Thalamocortical, Spike-and-wave discharges
CNS & Neurological Disorders - Drug Targets
Title: T-Type Calcium Channels and Thalamocortical Rhythms in Sleep: A Perspective from Studies of T-Type Calcium Channel Knockout Mice
Volume: 6 Issue: 1
Author(s): Jungryun Lee and Hee-Sup Shin
Affiliation:
Keywords: EEG oscillations, Inhibitory postsynaptic potential, Electromyogram, Thalamocortical, Spike-and-wave discharges
Abstract: Sleep is characterized by synchronized electrical activities of the thalamocortical network, which can be identified as the EEG oscillations during sleep. T-type calcium channels have been implicated in the occurrence of sleep waves, and burst firings in the thalamic neurons driven by these channels are known to be essential for modulation of sleep rhythms. Studies showed that α1G T-type calcium channel knockout mice had defects in sleep waves such as lack of delta oscillations (1-4 Hz) and alteration of sleep spindles (7-15 Hz), which are known to be modulated by T-currents in the thalamus. The mutation also affected the sleep-wake transition, thus resulting in decreased NREM sleep and increased sleep disturbance. These findings support the idea that α1G T-type calcium channels contribute to sleep waves as well as to behavioral state of sleep.
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Cite this article as:
Lee Jungryun and Shin Hee-Sup, T-Type Calcium Channels and Thalamocortical Rhythms in Sleep: A Perspective from Studies of T-Type Calcium Channel Knockout Mice, CNS & Neurological Disorders - Drug Targets 2007; 6 (1) . https://dx.doi.org/10.2174/187152707779940817
DOI https://dx.doi.org/10.2174/187152707779940817 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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