Drug Interactions of Tipranavir, a New HIV Protease Inhibitor

Title: Drug Interactions of Tipranavir, a New HIV Protease Inhibitor

Volume: 1 Issue: 1

Author(s): Judit Morello, Sonia Rodriguez-Novoa, Inmaculada Jimenez-Nacher and Vincent Soriano

Affiliation:

Keywords: Tipranavir, HIV, drug interactions, protease inhibitors

Abstract: Tipranavir is one of the latest approved HIV protease inhibitors. This non-peptidic molecule is an strong inducer of cytochrome P450 and has to be co-administered with low doses ritonavir as pharmacokinetic booster to achieve effective antiviral activity in vivo. As expected, significant drug interactions may occur in patients treated with tipranavir/ ritonavir, including diminished exposure to some antiretroviral agents. Although a few interactions can be managed with adequate drug dosing others preclude to use these medications in combination.

Cite this article as:

Morello Judit, Rodriguez-Novoa Sonia, Jimenez-Nacher Inmaculada and Soriano Vincent, Drug Interactions of Tipranavir, a New HIV Protease Inhibitor, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814256