Abstract
The investigations demonstrated clearly a unique function and role of endogenous formaldehyde (HCHO) and ozone (O3) in the antibiotic effect of diverse molecules having different chemical structure. Elimination of HCHO and/or O3 from the layer chromatographic spots resulted in a decrease in the antimicrobial activity. On the basis of detection and measure of endogenous HCHO and O3 BioArena enables to both direct isolation and biological evaluation of new bioactive compounds.
Keywords: Antibiotic, BioArena, cell proliferation, direct bioautography, formaldehyde, hydroxymethyl group, OPLC, ozone, troposphere, drug
Medicinal Chemistry
Title: BioArena Studies: Unique Function of Endogenous Formaldehyde and Ozone in the Antibiotic Effect – A Review
Volume: 8 Issue: 1
Author(s): Erno Tyihak, Agnes M. Moricz and Peter G. Ott
Affiliation:
Keywords: Antibiotic, BioArena, cell proliferation, direct bioautography, formaldehyde, hydroxymethyl group, OPLC, ozone, troposphere, drug
Abstract: The investigations demonstrated clearly a unique function and role of endogenous formaldehyde (HCHO) and ozone (O3) in the antibiotic effect of diverse molecules having different chemical structure. Elimination of HCHO and/or O3 from the layer chromatographic spots resulted in a decrease in the antimicrobial activity. On the basis of detection and measure of endogenous HCHO and O3 BioArena enables to both direct isolation and biological evaluation of new bioactive compounds.
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Cite this article as:
Tyihak Erno, M. Moricz Agnes and G. Ott Peter, BioArena Studies: Unique Function of Endogenous Formaldehyde and Ozone in the Antibiotic Effect – A Review, Medicinal Chemistry 2012; 8 (1) . https://dx.doi.org/10.2174/157340612799278388
DOI https://dx.doi.org/10.2174/157340612799278388 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
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Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
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