Abstract
This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.
Keywords: Eosinophils, escape mechanisms, IgE, immunomodulation, mast cells, T helper 1, T helper 2, trichinellosis, parasite, Trichinella, T. spiralis, T. nativa, T. murrelli, Type II diabetes
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?
Volume: 12 Issue: 1
Author(s): Fabrizio Bruschi and Lorena Chiumiento
Affiliation:
Keywords: Eosinophils, escape mechanisms, IgE, immunomodulation, mast cells, T helper 1, T helper 2, trichinellosis, parasite, Trichinella, T. spiralis, T. nativa, T. murrelli, Type II diabetes
Abstract: This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.
Export Options
About this article
Cite this article as:
Bruschi Fabrizio and Chiumiento Lorena, Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?, Endocrine, Metabolic & Immune Disorders - Drug Targets 2012; 12 (1) . https://dx.doi.org/10.2174/187153012799279081
DOI https://dx.doi.org/10.2174/187153012799279081 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Infectious Causes of Childhood Disability
Infectious Disorders - Drug Targets Structural Disorder within the Measles Virus Nucleoprotein and Phosphoprotein
Protein & Peptide Letters Hendra and Nipah Viruses: Pathogenesis and Therapeutics
Current Molecular Medicine A V<sub>L</sub>-linker-V<sub>H</sub> orientation dependent single chain variable antibody fragment against rabies virus G protein with enhanced neutralizing potency in vivo.
Protein & Peptide Letters Adenosine A1 Receptors in the Central Nervous System: Their Functions in Health and Disease, and Possible Elucidation by PET Imaging
Current Medicinal Chemistry Design, Synthesis and Biological Evaluation of Antipicornaviral Pyrrole-Containing Peptidomimetics
Protein & Peptide Letters Innovative Methodology in the Discovery of Novel Drug Targets in the Free-Living Amoebae
Current Drug Targets Alzheimer’s Disease and Molecular Chaperones: Current Knowledge and the Future of Chaperonotherapy
Current Pharmaceutical Design Models in Research of Pharmacoresistant Epilepsy: Present and Future in Development of Antiepileptic Drugs
Current Medicinal Chemistry Disease Modifying Approaches for Alzheimers Pathology
Current Pharmaceutical Design HIV-1 Capsid Inhibitors as Antiretroviral Agents
Current HIV Research Targeting Protozoan Parasite Metabolism: Glycolytic Enzymes in the Therapeutic Crosshairs
Current Medicinal Chemistry Exosomes and the Emerging Field of Exosome-Based Gene Therapy
Current Gene Therapy PDZ Domain-mediated Protein Interactions: Therapeutic Targets in Neurological Disorders
Current Medicinal Chemistry Advances in Drug Delivery from Nose to Brain: An Overview
Current Drug Therapy The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind
Current Neuropharmacology PI3K-Akt Signaling and Viral Infection
Recent Patents on Biotechnology Innate Immunity in Alzheimer’s Disease: A Complex Affair
CNS & Neurological Disorders - Drug Targets Pediatric Epilepsy Surgery: Neuropsychological and Psychosocial Outcomes
Current Pediatric Reviews Severe Influenza: Clinical Features and Treatment Options
Current Respiratory Medicine Reviews