Abstract
This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.
Keywords: Eosinophils, escape mechanisms, IgE, immunomodulation, mast cells, T helper 1, T helper 2, trichinellosis, parasite, Trichinella, T. spiralis, T. nativa, T. murrelli, Type II diabetes
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?
Volume: 12 Issue: 1
Author(s): Fabrizio Bruschi and Lorena Chiumiento
Affiliation:
Keywords: Eosinophils, escape mechanisms, IgE, immunomodulation, mast cells, T helper 1, T helper 2, trichinellosis, parasite, Trichinella, T. spiralis, T. nativa, T. murrelli, Type II diabetes
Abstract: This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.
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Bruschi Fabrizio and Chiumiento Lorena, Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?, Endocrine, Metabolic & Immune Disorders - Drug Targets 2012; 12 (1) . https://dx.doi.org/10.2174/187153012799279081
DOI https://dx.doi.org/10.2174/187153012799279081 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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