Abstract
Genes coding for members of the alpha/beta hydrolase fold superfamily of proteins are present in all known genomes. Although there is no common and essential function performed by these proteins shared in all living organisms, this fold has been used for a number of diverse functions. The ancestry of both enzymatic and protein-protein interaction capability of this structural scaffold made it an important tinkering tool kit for protein function evolution. Recently, enzymes known since a long time have been found to have a second function in acting promiscuously on alternative substrates, or to be true moonlighting proteins acting also as transporters, receptors, chaperones… The reverse situation has been encountered for adhesion proteins shown to be enzymes. This review, while not exhaustive, surveys some of the best-known examples of multiple functions in alpha/beta hydrolase fold proteins.
Keywords: Alpha/beta hydrolase fold, catalytic site, cholinesterase, enzyme, partnership, structure-function relationship, Genes, transporters, receptors, chaperones
Protein & Peptide Letters
Title: Enzymatic Activity and Protein Interactions in Alpha/Beta Hydrolase Fold Proteins: Moonlighting Versus Promiscuity
Volume: 19 Issue: 2
Author(s): Pascale Marchot and Arnaud Chatonnet
Affiliation:
Keywords: Alpha/beta hydrolase fold, catalytic site, cholinesterase, enzyme, partnership, structure-function relationship, Genes, transporters, receptors, chaperones
Abstract: Genes coding for members of the alpha/beta hydrolase fold superfamily of proteins are present in all known genomes. Although there is no common and essential function performed by these proteins shared in all living organisms, this fold has been used for a number of diverse functions. The ancestry of both enzymatic and protein-protein interaction capability of this structural scaffold made it an important tinkering tool kit for protein function evolution. Recently, enzymes known since a long time have been found to have a second function in acting promiscuously on alternative substrates, or to be true moonlighting proteins acting also as transporters, receptors, chaperones… The reverse situation has been encountered for adhesion proteins shown to be enzymes. This review, while not exhaustive, surveys some of the best-known examples of multiple functions in alpha/beta hydrolase fold proteins.
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Cite this article as:
Marchot Pascale and Chatonnet Arnaud, Enzymatic Activity and Protein Interactions in Alpha/Beta Hydrolase Fold Proteins: Moonlighting Versus Promiscuity, Protein & Peptide Letters 2012; 19 (2) . https://dx.doi.org/10.2174/092986612799080284
DOI https://dx.doi.org/10.2174/092986612799080284 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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