Abstract
The biological activities and mechanisms of tea polyphenols and their polymerics have been attractive issues in cancer research. The inhibition of tea polyphenols on cancer cells decreased cell proliferation and increased apoptosis. Tremendous evidences have shown that tea polyphenols suppress tumor promotion by inhibiting enzyme activities and blocking signal transduction pathways. Specifically, the mitogen activated protein kinases (MAPK) pathways have been implicated as an important target molecular for cancer prevention and therapy. The purpose of this review is to discuss the relationship between tea polyphenols and MAPK signaling pathways in cancer.
Keywords: Cancer, EGCG, kinases, MAPK, signaling pathways, tea polyphenols, apoptosis, TF3, ERK1/2, MEK1/2, neurodegenerative, morphological
Mini-Reviews in Medicinal Chemistry
Title: Effects of Tea Polyphenols and their Polymers on MAPK Signaling Pathways in Cancer Research
Volume: 12 Issue: 2
Author(s): W. Li, X. Mei and Y. Y. Tu
Affiliation:
Keywords: Cancer, EGCG, kinases, MAPK, signaling pathways, tea polyphenols, apoptosis, TF3, ERK1/2, MEK1/2, neurodegenerative, morphological
Abstract: The biological activities and mechanisms of tea polyphenols and their polymerics have been attractive issues in cancer research. The inhibition of tea polyphenols on cancer cells decreased cell proliferation and increased apoptosis. Tremendous evidences have shown that tea polyphenols suppress tumor promotion by inhibiting enzyme activities and blocking signal transduction pathways. Specifically, the mitogen activated protein kinases (MAPK) pathways have been implicated as an important target molecular for cancer prevention and therapy. The purpose of this review is to discuss the relationship between tea polyphenols and MAPK signaling pathways in cancer.
Export Options
About this article
Cite this article as:
Li W., Mei X. and Y. Tu Y., Effects of Tea Polyphenols and their Polymers on MAPK Signaling Pathways in Cancer Research, Mini-Reviews in Medicinal Chemistry 2012; 12 (2) . https://dx.doi.org/10.2174/138955712798995011
DOI https://dx.doi.org/10.2174/138955712798995011 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Plant Cells as Pharmaceutical Factories
Current Pharmaceutical Design Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target
Current Cancer Therapy Reviews Development of Lymphatic Vessels: Tumour Lymphangiogenesis and Lymphatic Invasion
Current Medicinal Chemistry Investigation of the Effect of <i>Prunus Amygdalus</i> Amara on the Expression of some Genes of Apoptosis and Immortality in Breast Cancer Cells (MCF- 7)
Current Drug Research Reviews Inhibition of Intercellular Communication between Prostate Cancer Cells by A Specific Anti-STEAP-1 Single Chain Antibody
Anti-Cancer Agents in Medicinal Chemistry Small-Molecule Chemokine Receptor Antagonists: Potential Targets for Inflammatory and Allergic Disorders
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Lentiviral Delivery of Proteins for Genome Engineering
Current Gene Therapy Highly Organized Nanostructures for Brain Drug Delivery - New Hope or Just a Fad?
CNS & Neurological Disorders - Drug Targets TRP Channels as Therapeutic Targets in Kidney Disease and Hypertension
Current Topics in Medicinal Chemistry Investigating the In Vivo Expression Patterns of miR-7 microRNA Family Members in the Adult Mouse Brain
MicroRNA Protecting Skin Photoaging by NF-κB Inhibitor
Current Drug Metabolism Growth Responses Following a Single Intra-Muscular hGH Plasmid Administration Compared to Daily Injections of hGH in Dwarf Mice
Current Gene Therapy The Role of Culture and Ethnicity in the Adjustment to Gynecological Cancer
Current Women`s Health Reviews A Constrained Probabilistic Matrix Decomposition Method for Predicting miRNA-disease Associations
Current Bioinformatics Apoptosis and Apoptosis-Based Therapy in Lung Cancer
Anti-Cancer Agents in Medicinal Chemistry Applications of FDG-PET/CT in Assessment of Vascular Infection and Inflammation
Current Molecular Imaging (Discontinued) Heme Oxygenase-1 in Tumor Biology and Therapy
Current Drug Targets Genetics of the First Seven Proprotein Convertase Enzymes in Health and Disease
Current Genomics Long Noncoding RNA GAS5: A Novel Marker Involved in Glucocorticoid Response
Current Molecular Medicine Smart Polymers and Their Role in Drug Delivery: A Review
Current Drug Therapy