Abstract
The tetraspanins constitute a conserved superfamily of four-span membrane proteins that are widely distributed in multi-cellular organisms. A characteristic property of tetraspanins is their ability to form lateral associations with one another and with other membrane proteins, giving rise to tetraspanin enriched microdomains (TEM) that are involved in the molecular organisation of many membrane-associated functions such as adhesion, fusion and trafficking. Increasing evidence suggests that intracellular pathogens, especially viruses, have “hijacked” tetraspanins as a means of entering, traversing and exiting cells during the course of infection. This article reviews current evidence for the role of tetraspanins in the uptake, trafficking and spread of viruses as well as intracellular bacteria, fungi and parasites. Finally, the prospects of targeting tetraspanins for therapeutic intervention in infections caused by such pathogens are discussed.
Keywords: Tetraspanins, membrane proteins, adhesion, infectious disease, four-span membrane proteins, enriched microdomains (TEM), trafficking, pathogens, glycoproteins
Infectious Disorders - Drug Targets
Title: Tetraspanins - Gateways for Infection
Volume: 12 Issue: 1
Author(s): Peter N. Monk and Lynda J. Partridge
Affiliation:
Keywords: Tetraspanins, membrane proteins, adhesion, infectious disease, four-span membrane proteins, enriched microdomains (TEM), trafficking, pathogens, glycoproteins
Abstract: The tetraspanins constitute a conserved superfamily of four-span membrane proteins that are widely distributed in multi-cellular organisms. A characteristic property of tetraspanins is their ability to form lateral associations with one another and with other membrane proteins, giving rise to tetraspanin enriched microdomains (TEM) that are involved in the molecular organisation of many membrane-associated functions such as adhesion, fusion and trafficking. Increasing evidence suggests that intracellular pathogens, especially viruses, have “hijacked” tetraspanins as a means of entering, traversing and exiting cells during the course of infection. This article reviews current evidence for the role of tetraspanins in the uptake, trafficking and spread of viruses as well as intracellular bacteria, fungi and parasites. Finally, the prospects of targeting tetraspanins for therapeutic intervention in infections caused by such pathogens are discussed.
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Cite this article as:
N. Monk Peter and J. Partridge Lynda, Tetraspanins - Gateways for Infection, Infectious Disorders - Drug Targets 2012; 12 (1) . https://dx.doi.org/10.2174/187152612798994957
DOI https://dx.doi.org/10.2174/187152612798994957 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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