Abstract
RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.
Keywords: siRNA, delivery, polymers, RNA interference, polyplexes, endosomal escape, in vivo, target cells, safety, mammalian cells, non-target sites, pharmacokinetics, amido amine, natural and synthetic polymers, intermolecular forces
Current Topics in Medicinal Chemistry
Title: Polymeric Carrier Systems for siRNA Delivery
Volume: 12 Issue: 2
Author(s): P. Vader, L. J. van der Aa, G. Storm, R. M. Schiffelers and J. F.J. Engbersen
Affiliation:
Keywords: siRNA, delivery, polymers, RNA interference, polyplexes, endosomal escape, in vivo, target cells, safety, mammalian cells, non-target sites, pharmacokinetics, amido amine, natural and synthetic polymers, intermolecular forces
Abstract: RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.
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Cite this article as:
Vader P., J. van der Aa L., Storm G., M. Schiffelers R. and F.J. Engbersen J., Polymeric Carrier Systems for siRNA Delivery, Current Topics in Medicinal Chemistry 2012; 12 (2) . https://dx.doi.org/10.2174/156802612798919123
DOI https://dx.doi.org/10.2174/156802612798919123 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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