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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Green Method for the Synthesis of 3-Substituted Coumarins Catalyzed by L-Lysine in Water Via Knoevenagel Condensation

Author(s): Xinwen You, Hua Yu, Mangang Wang, Jun Wu and Zhicai Shang

Volume 9, Issue 1, 2012

Page: [19 - 23] Pages: 5

DOI: 10.2174/157017812799303953

Price: $65

Abstract

L-lysine was applied to the synthesis of 3-substituted coumarins through the condensation of various salicylaldehyde with reactive methylene compounds in water. In this work, waste minimization, catalyst recovery, simple operation and easier product work-up were achieved.

Keywords: Coumarins, green chemistry, knoevenagel condensation, L-lysine, water, optical brightening agents, fluorescent, laser dyes, ethyl acetoacetate, microwave irradiation


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