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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro

Author(s): Ling-Ling Fan, Ning Huang, Rui-Ge Yang, Shu-Zhen He, Liu-Meng Yang, Hui Xu and Yong-Tang Zheng

Volume 9, Issue 1, 2012

Page: [44 - 47] Pages: 4

DOI: 10.2174/157018012798193026

Price: $65

Abstract

In continuation of our program to find compounds with potent anti-human immunodeficiency virus type 1 (HIV-1) activities, seventeen 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives (1-17) were preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 10 and 17 showed the most potent anti-HIV-1 activities with EC50 values of 2.42 and 3.39 μg/mL, and TI values of 63.76 and 53.60, respectively.

Keywords: 5,6-Dihydro-indolo[1,2-a]quinoxaline, Acquired immunodeficiency syndrome, Human immunodeficiency virus-1, Inhibitor, AIDS, quinoxaline, HIV-1, Syncytia Assay, MTT-based Cytotoxicity Assay, TCID50, calf serum, Anti-HIV-1 Activity Assay, HIV-1 IIIB, Reed and Muench method


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