Abstract
Lung cancer is one of the most common cancers but treatment has limited success and survival rates remain low. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has anti-proliferative and pro-apoptotic actions in lung carcinoma cell lines in vitro. Vitamin D deficiency is associated with poor prognosis in lung cancer, and lung cancer survival varies according to vitamin D receptor genotype. Randomized controlled trials should be performed to determine whether vitamin D supplementation might have a role as an adjunct to conventional treatments for lung cancer.
Keywords: Vitamin D, lung cancer, incidence, mortality, chemotherapy, radiotherapy, NSCLC, anti-angiogenic, pro-apoptotic, vitamin D supplementation
Current Respiratory Medicine Reviews
Title: Vitamin D and Lung Cancer
Volume: 7 Issue: 6
Author(s): Helga Rhein
Affiliation:
Keywords: Vitamin D, lung cancer, incidence, mortality, chemotherapy, radiotherapy, NSCLC, anti-angiogenic, pro-apoptotic, vitamin D supplementation
Abstract: Lung cancer is one of the most common cancers but treatment has limited success and survival rates remain low. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has anti-proliferative and pro-apoptotic actions in lung carcinoma cell lines in vitro. Vitamin D deficiency is associated with poor prognosis in lung cancer, and lung cancer survival varies according to vitamin D receptor genotype. Randomized controlled trials should be performed to determine whether vitamin D supplementation might have a role as an adjunct to conventional treatments for lung cancer.
Export Options
About this article
Cite this article as:
Rhein Helga, Vitamin D and Lung Cancer, Current Respiratory Medicine Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339811798072649
DOI https://dx.doi.org/10.2174/157339811798072649 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Huntingtons Disease: New Frontiers for Molecular and Cell Therapy
Current Drug Targets It is All About Proteases: From Drug Delivery to In Vivo Imaging and Photomedicine
Current Medicinal Chemistry Oncorine, the World First Oncolytic Virus Medicine and its Update in China
Current Cancer Drug Targets Vinorelbine in Cancer Therapy
Current Drug Targets VEGF Inhibitors and Prostate Cancer Therapy
Current Molecular Pharmacology High Throughput Screening for Protein Kinase Inhibitors
Combinatorial Chemistry & High Throughput Screening Nitroimidazoles as Anti-Tumor Agents
Anti-Cancer Agents in Medicinal Chemistry Advances in Nanocarriers for Anticancer Drugs Delivery
Current Medicinal Chemistry Phytochemicals as Adjunctive with Conventional Anticancer Therapies
Current Pharmaceutical Design The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies
Current Cancer Drug Targets Polymers and Drug Delivery Systems
Current Drug Delivery The Engaged Role of Tumor Microenvironment in Cancer Metabolism: Focusing on Cancer-Associated Fibroblast and Exosome Mediators
Anti-Cancer Agents in Medicinal Chemistry Biological Drugs in Guillain-Barré Syndrome: An Update
Current Neuropharmacology Hematological Targets of Radiation Damage
Current Drug Targets The Acute Phase Protein α1-Acid Glycoprotein: A Model for Altered Glycosylation During Diseases
Current Protein & Peptide Science Emerging Family of Protein-protein Interaction Inhibitors Targeting PD-1 Checkpoint Pathway
Current Cancer Therapy Reviews To Cardiovascular Disease and Beyond: New Therapeutic Perspectives of Statins in Autoimmune Diseases and Cancer
Current Drug Targets GSTP1 Polymorphisms and their Association with Glutathione Transferase and Peroxidase Activities in Patients with Motor Neuron Disease
CNS & Neurological Disorders - Drug Targets Heterologous Production of Death Ligands’ and Death Receptors’ Extracellular Domains: Structural Features and Efficient Systems
Protein & Peptide Letters Targeting the Wingless Signaling Pathway with Natural Compounds as Chemopreventive or Chemotherapeutic Agents
Current Pharmaceutical Biotechnology