Synthesis and in vitro Leishmanicidal Activity of Disulfide Derivatives

Title: Synthesis and in vitro Leishmanicidal Activity of Disulfide Derivatives

Volume: 7 Issue: 6

Author(s): Khalid Mohammed Khan, Muhammad Taha, Farzana Naz, Momin Khan, Fazal Rahim, Samreen, Shahnaz Perveen and M. Iqbal Choudhary

Affiliation:

Keywords: Synthesis, disulfides, leishmanicidal activity, Leishmania, spectroscopic techniques, pentamidine, protozoan, Nicolle, genus Leishmania, disulfide linkage

Abstract: Disulfides 1-30 have been synthesized and their in vitro leishmanicidal activity has been evaluated. Compounds 18 (IC50 = 2.70 ± 0.044 μM), 19 (IC50 = 2.85 ± 0.02 μM), 20 (IC50 = 2.92 ± 0.01 μM), 26 (IC50 = 3.69 ± 0.01 μM), 21 (IC50 = 4.45 ± 0.029 μM), and 29 (IC50 = 4.46 ± 0.025 μM) showed a remarkable leishmanicidal activity if compared with standard pentamidine (IC50 = 5.09 ± 0.04 μM). This study has discovered a series of possible molecules as antileishmanial agents. A structure-activity relationship study has also been carried out. The structures of all the synthesized compounds were identified by using spectroscopic techniques, including 1H-NMR and EI MS.

Cite this article as:

Mohammed Khan Khalid, Taha Muhammad, Naz Farzana, Khan Momin, Rahim Fazal, Samreen , Perveen Shahnaz and Iqbal Choudhary M., Synthesis and in vitro Leishmanicidal Activity of Disulfide Derivatives, Medicinal Chemistry 2011; 7 (6) . https://dx.doi.org/10.2174/157340611797928460