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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis, Structural Determination of a New Ocotillol Derivative and its Epimer

Author(s): Meng Qingguo, Bi Yi, Wang Liang, Jiang Naicaiv, Jiang Yongtao, Zhang Jiangfeng, Yi Songtao and Sun Haijun

Volume 8, Issue 9, 2011

Page: [682 - 685] Pages: 4

DOI: 10.2174/157017811799304377

Price: $65

Abstract

Epimeric 20S, 24-epoxy-dammarane-3β, 6α, 12β, 25-tetraol acetic ester was synthesized from 20(S)- protopanaxatriol in the presence of acetic anhydride and the product oxidated by m-CPBA. 20S, 24R-epoxy dammarane- 3β, 6α, 12β, 25-tetraol (ocotillol derivative) and its epimer were synthesized by saponification in the presence of sodium hydroxide in 1:1 molar ratio. The structures of the two compounds were characterized by X-ray diffraction method. The results showed the configuration of C-24 of two epimers as S-form (4, ocotillol derivative) and R-form (3, epimer), respectively.

Keywords: Ocotillol, derivative, epimer, synthesis, structure determination, ginsenoside, isoproterenol, ocotillol derivative, protopanaxadiol, saponin, protopanaxatriol, semi-solid, ORTEP representations


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