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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Titanocene Dichloride as an Efficient Catalyst for One-Pot Synthesis of α-Aminophosphonates

Author(s): Hong-Ying Niu, Hui-Juan Li, Jian-Ping Li, Yu Huang, Run-Ze Mao, De-Yang Li, Gui-Rong Qu and Hai-Ming Guo

Volume 8, Issue 9, 2011

Page: [674 - 681] Pages: 8

DOI: 10.2174/157017811799304359

Price: $65

Abstract

Commercially available titanocene dichloride was firstly used as an extremely efficient catalyst for a three component one-pot reaction of an amine, an aldehyde (ketone), and a dialkyl phosphite to form α-aminophosphonates under solvent-free conditions at ambient temperature in good to high yields, providing a green, rapid and convenient method for the synthesis of α-aminophosphonates.

Keywords: α-Aminophosphonates, multi-component reaction, titanocene dichloride, Aminophosphonates, titanocene, dichloride, multi-component reaction., antitumor agents, serine hydrolases, peptidomimetics, pharmacogenetical agents, enzyme, inhibitors


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