Recent Advances in the Applications of Ionic Liquids for the Synthesis of Bioactive Six-Membered N-Heterocycles

Jhillu      S. Yadav; Aneesh      Antony; B.      V. Subba Reddy

Abstract

N-heterocyclic compounds, which constitute a major portion of heterocyclic compounds are present in many parmaceutical products that mimic the biological activity of natural products. Access to these complex structures became available through a variety of novel methods and the strategic deployment of known methods. Because of the current trend in environmental protection, which has resulted in more restrictive environmental regulations, as well as the high costs of waste treatment, removal and remediation, the exploration for the synthesis of pharmacophores has reached a new phase in research. Ionic liquids have been identified as having significant potential for contributing to this process. Although ionic liquids were initially introduced as an alternative green reaction media because of their unique chemical and physical properties, the fact that they play a significant role in controlling reactions as a solvent or catalyst directs the research toward the development of a number of viable strategies.

Keywords: Ionic liquids, room temperature ionic liquids, green chemistry, N-heterocycles, pharmacophore, natural products, biological activity, SYNTHESIS OF PYRIDINES