Abstract
Nucleoside chemistry represents an important research area for drug discovery, as many nucleoside analogues are prominent drugs that have been widely applied in cancer and viral chemotherapy. However, the synthesis of modified nucleosides presents a major challenge. Most of the currently available methods require toxic, high-boiling solvents, long reaction times and tedious workup methods. The situation is further aggravated by the poor solubility of the nucleosides in common organic solvents. There is a constant effort to develop process chemistry in alternative media to limit the use of organic solvents that are hazardous to the environment and can be deleterious to human health. Ionic liquids (ILs) are ‘designer materials’ with unique physico-chemical properties. The methodologies utilizing ionic liquids for the synthesis of pharmaceutically important nucleoside analogues, including some antiviral drugs, are highly convenient and efficient. This article is focused on the recent developments made in nucleoside chemistry using ILs as a reaction medium.
Keywords: Nucleosides, ionic liquids, solubility, antiviral drugs, Neoteric Solvents, Nucleoside Chemistry, Biocatalytic Approach, SUGAR MODIFICATION
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
21