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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Most Recent Developments and Modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan Derivatives

Author(s): L. Stavitskaya and A. Coop

Volume 11, Issue 12, 2011

Page: [1002 - 1008] Pages: 7

DOI: 10.2174/138955711797247752

Price: $65

Abstract

The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.

Keywords: Opioid agonist, opioid antagonist, 14-alkoxymorphinans, 14-amino-4,5-epoxymorphinan derivatives, 14-Oheterocyclic naltrexones, morphine, opiates, SAR, analgesics, 14-position

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