Abstract
The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.
Keywords: Opioid agonist, opioid antagonist, 14-alkoxymorphinans, 14-amino-4,5-epoxymorphinan derivatives, 14-Oheterocyclic naltrexones, morphine, opiates, SAR, analgesics, 14-position
Mini-Reviews in Medicinal Chemistry
Title: Most Recent Developments and Modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan Derivatives
Volume: 11 Issue: 12
Author(s): L. Stavitskaya and A. Coop
Affiliation:
Keywords: Opioid agonist, opioid antagonist, 14-alkoxymorphinans, 14-amino-4,5-epoxymorphinan derivatives, 14-Oheterocyclic naltrexones, morphine, opiates, SAR, analgesics, 14-position
Abstract: The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.
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Cite this article as:
Stavitskaya L. and Coop A., Most Recent Developments and Modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan Derivatives, Mini-Reviews in Medicinal Chemistry 2011; 11 (12) . https://dx.doi.org/10.2174/138955711797247752
DOI https://dx.doi.org/10.2174/138955711797247752 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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