Abstract
4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.
Keywords: Crystal structure, HMG-CoA reductase, hydrogenation, pravastatin, 4, 5, 6, 7-tetrahydropravastatin, Tetrahydropravastatin, Staphylococcus aureus, SARs, HMG-CoA, CHD, Atherosclerotic, LDL-C, rhabdomoylsis, Elemental analyses
Letters in Drug Design & Discovery
Title: Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor
Volume: 8 Issue: 9
Author(s): Jing Li, Huan Li and Lei Zhang
Affiliation:
Keywords: Crystal structure, HMG-CoA reductase, hydrogenation, pravastatin, 4, 5, 6, 7-tetrahydropravastatin, Tetrahydropravastatin, Staphylococcus aureus, SARs, HMG-CoA, CHD, Atherosclerotic, LDL-C, rhabdomoylsis, Elemental analyses
Abstract: 4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.
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Cite this article as:
Li Jing, Li Huan and Zhang Lei, Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor, Letters in Drug Design & Discovery 2011; 8 (9) . https://dx.doi.org/10.2174/157018011797200876
DOI https://dx.doi.org/10.2174/157018011797200876 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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