Abstract
TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.
Keywords: Transient receptor potential, TRP channel, TRPA1, pain, asthma, inflammatory, non-selective cation channels, broad spectrum of chemical irritants, endogenous inflammatory compounds, inflammation raises, therapeutic potential, agonists, antagonists, TRPA1 modulators, genomic analysis
Current Topics in Medicinal Chemistry
Title: Transient Receptor Potential A1 Modulators
Volume: 11 Issue: 17
Author(s): Tim Strassmaier and Rajagopal Bakthavatchalam
Affiliation:
Keywords: Transient receptor potential, TRP channel, TRPA1, pain, asthma, inflammatory, non-selective cation channels, broad spectrum of chemical irritants, endogenous inflammatory compounds, inflammation raises, therapeutic potential, agonists, antagonists, TRPA1 modulators, genomic analysis
Abstract: TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.
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Cite this article as:
Strassmaier Tim and Bakthavatchalam Rajagopal, Transient Receptor Potential A1 Modulators, Current Topics in Medicinal Chemistry 2011; 11 (17) . https://dx.doi.org/10.2174/156802611796904915
DOI https://dx.doi.org/10.2174/156802611796904915 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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