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Current Immunology Reviews (Discontinued)

Editor-in-Chief

ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Generation of Regulatory T Cells to Antigen Expressed in the Retina

Author(s): Scott W. McPherson, Neal D. Heuss, Ute Lehmann and Dale S. Gregerson

Volume 7, Issue 3, 2011

Page: [344 - 349] Pages: 6

DOI: 10.2174/157339511796196584

Price: $65

Abstract

Regulatory T cells (Tregs) are generated to antigens (Ag) found in the retina. Some Tregs are the result of ectopic expression of the retinal Ags in the thymus, where developing T cells are committed to enter the regulatory lineage. However, the generation of retinal Ag-specific Tregs independent of the thymus was uncertain. Our studies show that Tregs can be generated from mature, peripheral T cells based on exposure to retinal Ags. These peripherally induced Tregs limited immune responses and experimental autoimmune disease induced by retinal Ags and thus constitute a crucial component of retinal immune privilege.

Keywords: Regulatory T cells, immune privilege, retina, Tregs, Ocular immune regulation, ocular tissue, Retinal Ags, Tregs mediated immune regulation, DTH response, immunoregulation


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