Abstract
The development of gadolinium chelators that can be easily and readily linked to various substrates is of primary importance for the development high relaxation efficiency and/or targeted magnetic resonance imaging (MRI) contrast agents. Over the last 25 years a large number of bifunctional chelators have been prepared. For the most part, these compounds are based on ligands that are already used in clinically approved contrast agents. More recently, new bifunctional chelators have been reported based on complexes that show a more potent relaxation effect, faster complexation kinetics and in some cases simpler synthetic procedures. This review provides an overview of the synthetic strategies used for the preparation of bifunctional chelators for MRI applications.
Keywords: Bifunctional chelator, Gadolinium, Magnetic Resonance Imaging, Lanthanide, Bioconjugate, Molecular Imaging, DOTA, DTPA, GdDTPA, GdDOTA derivatives
Current Organic Synthesis
Title: Strategies for the Preparation of Bifunctional Gadolinium(III) Chelators
Volume: 8 Issue: 4
Author(s): Luca Frullano and Peter Caravan
Affiliation:
Keywords: Bifunctional chelator, Gadolinium, Magnetic Resonance Imaging, Lanthanide, Bioconjugate, Molecular Imaging, DOTA, DTPA, GdDTPA, GdDOTA derivatives
Abstract: The development of gadolinium chelators that can be easily and readily linked to various substrates is of primary importance for the development high relaxation efficiency and/or targeted magnetic resonance imaging (MRI) contrast agents. Over the last 25 years a large number of bifunctional chelators have been prepared. For the most part, these compounds are based on ligands that are already used in clinically approved contrast agents. More recently, new bifunctional chelators have been reported based on complexes that show a more potent relaxation effect, faster complexation kinetics and in some cases simpler synthetic procedures. This review provides an overview of the synthetic strategies used for the preparation of bifunctional chelators for MRI applications.
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Cite this article as:
Frullano Luca and Caravan Peter, Strategies for the Preparation of Bifunctional Gadolinium(III) Chelators, Current Organic Synthesis 2011; 8 (4) . https://dx.doi.org/10.2174/157017911796117250
DOI https://dx.doi.org/10.2174/157017911796117250 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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