Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Novel Synthesis of Ibutilide Fumarate

Author(s): Tao Wang, Rui Tian, Bin Xiao, Yi Shen, Hui Zhou and Qingeng Li

Volume 8, Issue 6, 2011

Page: [423 - 426] Pages: 4

DOI: 10.2174/157017811796064412

Price: $65

Abstract

A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.

Keywords: Friedel-Crafts acylation, Ibutilide, synthesis, fumarate, antiarrhythmic, pyrrolidinone, repolarization, extravascular distribution, cardioversion, methylsulfonyl


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy