Importance of Oxidative Damage on the Electron Transport Chain for the Rational Use of Mitochondria-Targeted Antioxidants

Title: Importance of Oxidative Damage on the Electron Transport Chain for the Rational Use of Mitochondria-Targeted Antioxidants

Volume: 11 Issue: 7

Author(s): C. Cortes-Rojo and A. R. Rodriguez-Orozco

Affiliation:

Keywords: Lipid peroxidation, thiol oxidation, iron, respiratory chain, MitoQ, ischemia-reperfusion, neurodegeneration, liver diseases, electron transport chain, ETC impairment, reactive oxygen species, mitochondrial damage

Abstract: The electron transport chain (ETC) has become a promising pharmacological target as ETC impairment by reactive oxygen species (ROS) has been detected in several diseases. Therefore, for a better understanding of the actions of mitochondria-targeted antioxidants, it must be considered the interplay between the sources of ROS during disease, the chemical interconversions of ROS and their differential reactivity with ETC components. This review contrasts these aspects with available data about mitochondrial damage in specific diseases to give an insight into the importance of ROS chemistry in the rational use of mitochondria-targeted antioxidants, putting emphasis on the case of MitoQ.

Cite this article as:

Cortes-Rojo C. and R. Rodriguez-Orozco A., Importance of Oxidative Damage on the Electron Transport Chain for the Rational Use of Mitochondria-Targeted Antioxidants, Mini-Reviews in Medicinal Chemistry 2011; 11 (7) . https://dx.doi.org/10.2174/138955711795906879