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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Stem Cell-Mediated Delivery of Therapies in the Treatment of Glioma

Author(s): G. Frosina

Volume 11, Issue 7, 2011

Page: [591 - 598] Pages: 8

DOI: 10.2174/138955711795906897

Price: $65

Abstract

High grade gliomas can be seldom controlled, due to the infiltrative nature of these tumors and the presence of cell populations resistant to radio- and chemotherapy. Current research aims to develop novel therapeutic approaches to track and eliminate the disseminated glioma-driving cells. Selected delivery of therapeutic agents taking advantage of the tropism of normal stem cells for glioma cells might be one.

Keywords: Glioma, stem, gene therapy, cancer, resistance, High grade, ADSC, bone morphogenetic protein, cytosine deaminase, cyclophosphamide, connexin 43, EGF, ganciclovir, mesenchymal stem cell


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