Abstract
Severity of respiratory syncytial virus (RSV) infection is subject to individual variation, and, accordingly, genetic determinants play a role in the risk of developing RSV lower respiratory tract infection (LRTI) in previously healthy infants. A twin study showed that 22% of the individual susceptibility to RSV LRTI is attributable to genetic factors. About half of the infants with RSV LRTI will develop post-bronchiolitis wheeze (PBW). It is unknown whether RSV LRTI and PBW have similar etiology. This systematic review aims to provide insight into the genetic factors influencing susceptibility to RSV LRTI and PBW. Published genetic associations of RSV LRTI with both single nucleotide polymorphisms (SNPs) and haplotypes are shown. Particularly SNPs in innate immunity genes are associated with the pathogenesis of RSV LRTI. However, no genetic variants associated with RSV LRTI have been exactly replicated in other cohorts. A limited number of studies have reported associations between SNPs and PBW, especially in chemokine and Th2 related genes. In conclusion, although RSV LRTI and PBW show similarities in clinical presentation, different genetic factors are important for the development of these diseases in young children.
Keywords: Respiratory syncytial virus, post-bronchiolitis wheeze, single nucleotide polymorphism, haplotype, genetic association, lower respiratory tract infection, etiology, SNPs, upper respiratory tract infection, Genetic determinants, Postbronchiolitis wheeze
Current Respiratory Medicine Reviews
Title: Genetic Determinants of Severe Respiratory Syncytial Virus Infection and Post-Bronchiolitis Wheeze: A Systematic Review
Volume: 7 Issue: 3
Author(s): Annemieke Schuurhof, Marthe Kok, Jan L.L. Kimpen, Louis Bont and Riny Janssen
Affiliation:
Keywords: Respiratory syncytial virus, post-bronchiolitis wheeze, single nucleotide polymorphism, haplotype, genetic association, lower respiratory tract infection, etiology, SNPs, upper respiratory tract infection, Genetic determinants, Postbronchiolitis wheeze
Abstract: Severity of respiratory syncytial virus (RSV) infection is subject to individual variation, and, accordingly, genetic determinants play a role in the risk of developing RSV lower respiratory tract infection (LRTI) in previously healthy infants. A twin study showed that 22% of the individual susceptibility to RSV LRTI is attributable to genetic factors. About half of the infants with RSV LRTI will develop post-bronchiolitis wheeze (PBW). It is unknown whether RSV LRTI and PBW have similar etiology. This systematic review aims to provide insight into the genetic factors influencing susceptibility to RSV LRTI and PBW. Published genetic associations of RSV LRTI with both single nucleotide polymorphisms (SNPs) and haplotypes are shown. Particularly SNPs in innate immunity genes are associated with the pathogenesis of RSV LRTI. However, no genetic variants associated with RSV LRTI have been exactly replicated in other cohorts. A limited number of studies have reported associations between SNPs and PBW, especially in chemokine and Th2 related genes. In conclusion, although RSV LRTI and PBW show similarities in clinical presentation, different genetic factors are important for the development of these diseases in young children.
Export Options
About this article
Cite this article as:
Schuurhof Annemieke, Kok Marthe, L.L. Kimpen Jan, Bont Louis and Janssen Riny, Genetic Determinants of Severe Respiratory Syncytial Virus Infection and Post-Bronchiolitis Wheeze: A Systematic Review, Current Respiratory Medicine Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339811795589450
DOI https://dx.doi.org/10.2174/157339811795589450 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genetic Variations of the Hemostatic System as Risk Factors for Venous and Arterial Thrombotic Disease
Current Genomics Management of Chemotherapy Induced Cardiomyopathy
Current Cardiology Reviews The Multiple Roles of Vitamin D in Human Health. A Mini-Review
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Synthetic Cannabinoids as Drugs of Abuse
Current Drug Abuse Reviews Oxidative Stress and Mitochondrial Impairment After Treatment with Anti-HIV Drugs: Clinical Implications
Current Pharmaceutical Design Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches
Current Pharmaceutical Design Splice Modification to Restore Functional Dystrophin Synthesis in Duchenne Muscular Dystrophy
Current Pharmaceutical Design Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old Puzzle
Current Drug Targets Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials
Current Pharmaceutical Design Mitochondrial Disorders in Adults
Current Molecular Medicine Pathophysiological Roles of Nitric Oxide: In the Heart and the Coronary Vasculature
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Persistent Pulmonary Hypertension of the Newborn: Physiology, Hemodynamic Assessment and Novel Therapies
Current Pediatric Reviews Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases
Current Stem Cell Research & Therapy Cardiac Calmodulin Kinase: A Potential Target for Drug Design
Current Medicinal Chemistry Viral Infection - A Cure for Type 1 Diabetes?
Current Medicinal Chemistry Highlighting Exosomes’ Function in Cardiovascular Diseases
Current Cardiology Reviews Pregnancy in Type 2 Diabetes Mellitus - Problems & Promises
Current Diabetes Reviews RAAS Inhibition and Cardiorenal Syndrome
Current Hypertension Reviews Novel Inflammatory Biomarkers in Cardiovascular Therapeutics
Current Medicinal Chemistry Inherited Copper Transport Disorders: Biochemical Mechanisms, Diagnosis, and Treatment
Current Drug Metabolism