Abstract
Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.
Keywords: DPPH Radical scavengers, N,N-dimethylbarbiturates, N,N-dimethylbarbituric acid, DPPH, scavenging activity, antioxidant, spectroscopic techniques, elemental analysis, Barbituric acid, n-propyl gallate
Medicinal Chemistry
Title: Synthesis and DPPH Radical Scavenging Activity of 5-Arylidene-N,Ndimethylbarbiturates
Volume: 7 Issue: 3
Author(s): Khalid Mohammed Khan, Momin Khan, Muhammad Ali, Muhammad Taha, Abdul Hameed, Sajjad Ali, Shahnaz Perveen and M. Iqbal Choudhary
Affiliation:
Keywords: DPPH Radical scavengers, N,N-dimethylbarbiturates, N,N-dimethylbarbituric acid, DPPH, scavenging activity, antioxidant, spectroscopic techniques, elemental analysis, Barbituric acid, n-propyl gallate
Abstract: Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.
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Cite this article as:
Mohammed Khan Khalid, Khan Momin, Ali Muhammad, Taha Muhammad, Hameed Abdul, Ali Sajjad, Perveen Shahnaz and Iqbal Choudhary M., Synthesis and DPPH Radical Scavenging Activity of 5-Arylidene-N,Ndimethylbarbiturates, Medicinal Chemistry 2011; 7 (3) . https://dx.doi.org/10.2174/157340611795564231
DOI https://dx.doi.org/10.2174/157340611795564231 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
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