Abstract
A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner – Wadsworth – Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
Keywords: Prostaglandins, antiglaucoma, (±) travoprost, Phosphonate, n-BuLi, dimethyl, methane, dimethoxyethane, alkylation
Letters in Organic Chemistry
Title: Synthesis of (±) Travoprost and its Analogs
Volume: 8 Issue: 4
Author(s): Harikrishna Mudduluru, Rama M. Hindupur, Pramod K. Dubey, Shankar Madhavaram, Lakshmikumar Tatini and Gottumukkala V. Subbaraju
Affiliation:
Keywords: Prostaglandins, antiglaucoma, (±) travoprost, Phosphonate, n-BuLi, dimethyl, methane, dimethoxyethane, alkylation
Abstract: A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner – Wadsworth – Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
Export Options
About this article
Cite this article as:
Mudduluru Harikrishna, M. Hindupur Rama, K. Dubey Pramod, Madhavaram Shankar, Tatini Lakshmikumar and V. Subbaraju Gottumukkala, Synthesis of (±) Travoprost and its Analogs, Letters in Organic Chemistry 2011; 8 (4) . https://dx.doi.org/10.2174/157017811795371485
DOI https://dx.doi.org/10.2174/157017811795371485 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Molecular and Cellular Basis of Atherosclerosis and Plaque Rupture
Current Cardiology Reviews Progress in the Rational Design for Polypharmacology Drug
Current Pharmaceutical Design Differential Expression of TOM34, AL1A1, PADI2 and KLRBA in NNK Induced Lung Cancer in Wistar Rats and their Implications
Current Cancer Drug Targets Cellular Senescence in Cardiovascular Diseases: Potential Age-Related Mechanisms and Implications for Treatment
Current Pharmaceutical Design The J-shaped Association Between Alcohol Consumption and Breast Cancer: A Case-Control Study
Current Nutrition & Food Science Probiotics in Curing Allergic and Inflammatory Conditions - Research Progress and Futuristic Vision
Recent Patents on Inflammation & Allergy Drug Discovery A beta oligomerization A Therapeutic Target for Alzheimers Disease
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Nanoparticulate Drug Delivery Systems for Treatment of Hepatocellular Carcinoma
Current Cancer Therapy Reviews Angiomodulatory and Neurological Effects of Ginsenosides
Current Medicinal Chemistry 7-prenyloxi-6-methoxycoumarin from Polygala sabulosa A.W. Bennett Regulates p38 MAPK and NF-kB Pathways Inhibiting the Inflammation Induced by Carrageenan in the Mouse Model of Pleurisy
Inflammation & Allergy - Drug Targets (Discontinued) Nur77 Family of Nuclear Hormone Receptors
Current Drug Targets - Inflammation & Allergy Probiotic Research in Australia, New Zealand and the Asia-Pacific Region
Current Pharmaceutical Design Antimicrobial Peptides of Marine Crustaceans: The Potential and Challenges of Developing Therapeutic Agents
Current Medicinal Chemistry Insulin, Thrombin, ERK1/2 Kinase and Vascular Smooth Muscle Cells Proliferation
Current Pharmaceutical Design COVID-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods
Anti-Cancer Agents in Medicinal Chemistry Gene Therapy in the Transplantation of Allogeneic Organs and Stem Cells
Current Gene Therapy Antiulcer Activity of Lemon (Citrus limon) Fruit Juice and Its Interaction with Conventionally used Antiulcer Drugs in Rats
The Natural Products Journal The Role of ABC and SLC Transporters in the Pharmacokinetics of Dietary and Herbal Phytochemicals and their Interactions with Xenobiotics
Current Drug Metabolism Determination of Flunixin in Swine Plasma, Urine and Feces by UPLCMS/ MS and its Application in the Real Samples
Current Pharmaceutical Analysis Innovations in siRNA Research: A Technology Comes of Age
Recent Patents on Anti-Infective Drug Discovery