Abstract
Cisplatin and its congeners are well-known to exert their therapeutic effects on cancer via interaction with DNA in the cell nucleus. On the other hand, the undesirable side-effects of these drugs appear to also be linked, at least to some extent, to interaction of the platinum with proteins and peptides. For other classes of anticancer drugs, interaction with proteins is in fact the primary pathway whereby therapeutically-useful effects are achieved. Here, a review is given of the known instances of interaction of cisplatin and related compounds with proteins and biologically relevant peptides, with emphasis on structural and reactivity aspects.
Keywords: Cisplatin, cysteine, methionine, adduct, toxicity, resistance, Interactions, Proteins, Platinum, Anti-Cancer, DNA, peptides, DNA-Processing Enzymes, Platinum-Binding Proteins
Mini-Reviews in Medicinal Chemistry
Title: Interactions Between Proteins and Platinum-Containing Anti-Cancer Drugs
Volume: 11 Issue: 3
Author(s): Cristina Bischin, Alexandru Lupan, Vicentiu Taciuc and Radu Silaghi-Dumitrescu
Affiliation:
Keywords: Cisplatin, cysteine, methionine, adduct, toxicity, resistance, Interactions, Proteins, Platinum, Anti-Cancer, DNA, peptides, DNA-Processing Enzymes, Platinum-Binding Proteins
Abstract: Cisplatin and its congeners are well-known to exert their therapeutic effects on cancer via interaction with DNA in the cell nucleus. On the other hand, the undesirable side-effects of these drugs appear to also be linked, at least to some extent, to interaction of the platinum with proteins and peptides. For other classes of anticancer drugs, interaction with proteins is in fact the primary pathway whereby therapeutically-useful effects are achieved. Here, a review is given of the known instances of interaction of cisplatin and related compounds with proteins and biologically relevant peptides, with emphasis on structural and reactivity aspects.
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Bischin Cristina, Lupan Alexandru, Taciuc Vicentiu and Silaghi-Dumitrescu Radu, Interactions Between Proteins and Platinum-Containing Anti-Cancer Drugs, Mini-Reviews in Medicinal Chemistry 2011; 11 (3) . https://dx.doi.org/10.2174/138955711795049844
DOI https://dx.doi.org/10.2174/138955711795049844 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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