Stem Cells in Brain Tumorigenesis and their Impact on Therapy

Andres      Felipe Cardona; Carmen      Balana; Diana      Torres; Henry      Becerra; Leon      Dario Ortiz; Camilo      E. Fadul

Abstract

The concept that the genesis of new cells in the adult mammalian brain is negligible has long influenced our perception and understanding of the origin and development of central nervous system (CNS) tumors. The discovery that neurons and glia are produced throughout life from neural stem cells provides new possibilities for candidate precursor cells of CNS neoplasms. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis. As such, opportunities become available to identify new therapeutic strategies.

Keywords: Brain tumor, glioma, stem cells, tumorigenesis, neurogenesis, development, genetics, molecular biology, central nervous system neoplasms, medulloblastoma