Abstract
Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.
Keywords: Enterovirus, antiviral agent, therapy, inhibition, viral encephalitis, capsid inhibitor, protease inhibitor, polymerase inhibitor, CNS complications, EV infection-related CNS syndromes, acute flaccid paralysis, aseptic meningitis, encephalitis, poliovirus, viral replication cycle
Infectious Disorders - Drug Targets
Title: Drug Discovery in Enteroviral Infections
Volume: 11 Issue: 3
Author(s): Tzu-Chun Chen and Shin-Ru Shih
Affiliation:
Keywords: Enterovirus, antiviral agent, therapy, inhibition, viral encephalitis, capsid inhibitor, protease inhibitor, polymerase inhibitor, CNS complications, EV infection-related CNS syndromes, acute flaccid paralysis, aseptic meningitis, encephalitis, poliovirus, viral replication cycle
Abstract: Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.
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Cite this article as:
Chen Tzu-Chun and Shih Shin-Ru, Drug Discovery in Enteroviral Infections, Infectious Disorders - Drug Targets 2011; 11 (3) . https://dx.doi.org/10.2174/187152611795768060
DOI https://dx.doi.org/10.2174/187152611795768060 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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