Abstract
A novel class of compounds with structure Aryl propyl acridone-4-carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.
Keywords: Aryl propyl acridone-4-carboxamides, Microwave, Chemosensitizing agents
Letters in Drug Design & Discovery
Title: Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer
Volume: 8 Issue: 3
Author(s): Vinaykumar S. Velingkar and Vikrant D. Dandekar
Affiliation:
Keywords: Aryl propyl acridone-4-carboxamides, Microwave, Chemosensitizing agents
Abstract: A novel class of compounds with structure Aryl propyl acridone-4-carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.
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Cite this article as:
S. Velingkar Vinaykumar and D. Dandekar Vikrant, Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer, Letters in Drug Design & Discovery 2011; 8 (3) . https://dx.doi.org/10.2174/157018011794578169
DOI https://dx.doi.org/10.2174/157018011794578169 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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