Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

Title: Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

Volume: 8 Issue: 3

Author(s): Tatjana G. Tolstikov, Mikhail V. Khvostov, Galina I. Lifshits, Alexander V. Dushkin and Elezaveta S. Meteleva

Affiliation:

Keywords: Arabinogalactan, Clathration, Glycyrrhizic acid, Warfarin

Abstract: The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacons anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).

Cite this article as:

G. Tolstikov Tatjana, V. Khvostov Mikhail, I. Lifshits Galina, V. Dushkin Alexander and S. Meteleva Elezaveta, Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan, Letters in Drug Design & Discovery 2011; 8 (3) . https://dx.doi.org/10.2174/157018011794578222