Abstract
This study was designed to assess the effect of honey supplementation and sugar-based hypercaloric regimen on weight gain and blood pressure (BP) in Wistar rats. Animals were fed for 8 weeks with standard diet (S-free) or a hypercaloric diet (standard chow and 30% sugar in drinking water), (SF), or standard chow supplemented with fat and honey and 10% sugar in drinking water (HF). Overall weight gain and body fat levels were significantly higher in SF and HF than in S-free. Fat cells were significantly larger in SF compared with HF. Compared with SF and S-free, HF had higher glucose, but triglycerides, and LDLc levels were not different. BP was significantly higher in SF but not in HF compared to S-free. These observations indicate that honey may afford a protection against increase in BP and in fat cell size resulting from a hypercaloric diet.
Keywords: Carbohydrate, Honey, Hypertension, Obesity, Rats, Fat cell size, weight gain, blood pressure, SF, HF, overweight, glucose, sucrose, fructose, metabolic syndrome, adipose tissue, dyslipidemia, cytokine, Diet, LDLc, enzymatic colorimetric kit, Histology, Tuckey test, Body Weight, adipocyte size, Plasma Glucose, Triglycerides, hypercaloric diet, metabolism, hypertrophy, hyperplasia
Letters in Drug Design & Discovery
Title: Effects of Honey Against the Accumulation of Adipose Tissue and the Increased Blood Pressure on Carbohydrate-Induced Obesity in Rat
Volume: 8 Issue: 1
Author(s): Samanta Romero-Silva, Miguel Angel Martinez R, Laura P. Romero-Romero, Oralia Rodriguez, C. Gerardo Salas G, Nicole Morel, Francisco Javier Lopez-Munoz, Luis Angel Lima-Mendoza and Guadalupe Bravo
Affiliation:
Keywords: Carbohydrate, Honey, Hypertension, Obesity, Rats, Fat cell size, weight gain, blood pressure, SF, HF, overweight, glucose, sucrose, fructose, metabolic syndrome, adipose tissue, dyslipidemia, cytokine, Diet, LDLc, enzymatic colorimetric kit, Histology, Tuckey test, Body Weight, adipocyte size, Plasma Glucose, Triglycerides, hypercaloric diet, metabolism, hypertrophy, hyperplasia
Abstract: This study was designed to assess the effect of honey supplementation and sugar-based hypercaloric regimen on weight gain and blood pressure (BP) in Wistar rats. Animals were fed for 8 weeks with standard diet (S-free) or a hypercaloric diet (standard chow and 30% sugar in drinking water), (SF), or standard chow supplemented with fat and honey and 10% sugar in drinking water (HF). Overall weight gain and body fat levels were significantly higher in SF and HF than in S-free. Fat cells were significantly larger in SF compared with HF. Compared with SF and S-free, HF had higher glucose, but triglycerides, and LDLc levels were not different. BP was significantly higher in SF but not in HF compared to S-free. These observations indicate that honey may afford a protection against increase in BP and in fat cell size resulting from a hypercaloric diet.
Export Options
About this article
Cite this article as:
Romero-Silva Samanta, Angel Martinez R Miguel, P. Romero-Romero Laura, Rodriguez Oralia, Gerardo Salas G C., Morel Nicole, Javier Lopez-Munoz Francisco, Angel Lima-Mendoza Luis and Bravo Guadalupe, Effects of Honey Against the Accumulation of Adipose Tissue and the Increased Blood Pressure on Carbohydrate-Induced Obesity in Rat, Letters in Drug Design & Discovery 2011; 8 (1) . https://dx.doi.org/10.2174/157018011793663912
DOI https://dx.doi.org/10.2174/157018011793663912 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cardiovascular Effects Mediated by Imidazoline Drugs: An Update
Cardiovascular & Hematological Disorders-Drug Targets Synaptic Inputs of Neural Afferent Pathways to Vasopressin- and Oxytocin-Secreting Neurons of Supraoptic and Paraventricular Hypothalamic Nuclei
Endocrine, Metabolic & Immune Disorders - Drug Targets Cardiovascular Disease in Primary Sjögren’s Syndrome
Reviews on Recent Clinical Trials Regulation of Catechins in Uric Acid Metabolism Disorder Related Human Diseases
Mini-Reviews in Medicinal Chemistry Editorial (Novel Therapies and Botanical and Mechanical Approaches for Management of Cardiovascular Disease)
Recent Patents on Cardiovascular Drug Discovery Regulation of Vascular Endothelial Nitric Oxide Production by Fatty Acids
Current Organic Chemistry Ischemic Colitis: Current Diagnosis and Treatment
Current Drug Targets Nitric Oxide and its Role During Pregnancy: From Ovulation to Delivery
Current Pharmaceutical Design Clinical Vignettes: Integrated Care of Cancer Patients by Oncologists and Cardiologists
Current Cardiology Reviews Venlafaxine and Risk of Upper Gastrointestinal Bleeding in Elderly Depression
Current Drug Safety Relation Between Obstructive Sleep Apnea Syndrome and Resistant Hypertension - The Tip of the Iceberg
Current Respiratory Medicine Reviews Human Umbilical Cord Mesenchymal Stem Cells Therapy for Insulin Resistance: A Novel Strategy in Clinical Implication
Current Stem Cell Research & Therapy α2-Antiplasmin on Cardiovascular Diseases
Current Pharmaceutical Design Flavonoids Health Benefits and Their Molecular Mechanism
Mini-Reviews in Medicinal Chemistry Fatty Acids and Obesity
Current Pharmaceutical Design The Physiology and Pathophysiology of a Novel Angiotensin Receptor-binding Protein ATRAP/Agtrap
Current Pharmaceutical Design Recent Developments in Studies of l-Stepholidine and its Analogs: Chemistry, Pharmacology and Clinical Implications
Current Medicinal Chemistry Osteoarthritis: Is there a Window of Opportunity
Current Rheumatology Reviews Small-Molecules Targeting Kinases Involved in Pulmonary Hypertension: a Patent Review (2010-2015)
Current Medicinal Chemistry Pharmacological, Immunological, and Gene Targeting of the Renin-Angiotensin System for Treatment of Cardiovascular Disease
Current Pharmaceutical Design