Catalytic Enantioselective Ring-Opening Reaction of meso-Epoxides with ArSeH Using a (Salen)Ti(IV) Complex

Title: Catalytic Enantioselective Ring-Opening Reaction of meso-Epoxides with ArSeH Using a (Salen)Ti(IV) Complex

Volume: 7 Issue: 7

Author(s): Minghua Yang, Ji Pei, Jiangtao Sun, Fang Yuan and Chengjian Zhu

Affiliation:

Keywords: Arylselenols, epoxides, ring-opening reaction, asymmetric catalysis, RNH2, ROH, TMSCN, RN3, RSH, mercaptoalcohols, Grignard reagents, scandium-bipyridine complex, selenophenol, Kozlowski's modular bifunctional salen ligands, Ring-Opening Reactiona, Schlenk techniques, NMR, Bruker AMX-300 spectrometer, mass spectrometer, chiral Chiralcel OD-H column, 2-(phenylseleno)-1-cyclohexanol, HPLC, 2-(phenylseleno)-1-cyclopentanol, 3-(phenylseleno)-2-butylol, 2-(naphthylseleno)-1-cyclohexanol

Abstract: Enantioselective ring-opening reaction of meso-epoxides with arylselenols using a chiral (salen)Ti(IV) complex as catalyst was realized, and 1,2- arylseleno alcohols were obtained in good yields and up to 80 % ee.

Cite this article as:

Yang Minghua, Pei Ji, Sun Jiangtao, Yuan Fang and Zhu Chengjian, Catalytic Enantioselective Ring-Opening Reaction of meso-Epoxides with ArSeH Using a (Salen)Ti(IV) Complex, Letters in Organic Chemistry 2010; 7 (7) . https://dx.doi.org/10.2174/157017810793362226