Abstract
This review addresses the current state of Lung Protective Ventilation and PEEP settings in critical ill patients, especially with Acute Respiratory Distress Syndrome (ARDS). Mechanisms of mediator and cytokine activation are described and results from clinical studies on mechanical ventilation are compared with results obtained in experimental studies. Furthermore, several ventilation strategies, particularly the Open Lung Maneuver, are discussed highlighting their role in the prevention of VALI. Finally, the Open Lung Maneuver is described through an example of an illustrative case.
Keywords: Adult respiratory distress syndrome, ventilator associated lung injury, PEEP, open lung maneuver, mechanical ventilation, cytokines, ARDS, septicemia, prostacyclin, tumor necrosis factor-, interleukin-6, High frequency oscillation, hyperoxia, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, acidosis, MRUPL, bronchoscopy, ventilator
Current Respiratory Medicine Reviews
Title: Optimizing Ventilation with the Open Lung Maneuver
Volume: 6 Issue: 4
Author(s): David Schwaiberger, Peter J. Papadakos and Burkhard Lachmann
Affiliation:
Keywords: Adult respiratory distress syndrome, ventilator associated lung injury, PEEP, open lung maneuver, mechanical ventilation, cytokines, ARDS, septicemia, prostacyclin, tumor necrosis factor-, interleukin-6, High frequency oscillation, hyperoxia, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, acidosis, MRUPL, bronchoscopy, ventilator
Abstract: This review addresses the current state of Lung Protective Ventilation and PEEP settings in critical ill patients, especially with Acute Respiratory Distress Syndrome (ARDS). Mechanisms of mediator and cytokine activation are described and results from clinical studies on mechanical ventilation are compared with results obtained in experimental studies. Furthermore, several ventilation strategies, particularly the Open Lung Maneuver, are discussed highlighting their role in the prevention of VALI. Finally, the Open Lung Maneuver is described through an example of an illustrative case.
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Cite this article as:
Schwaiberger David, J. Papadakos Peter and Lachmann Burkhard, Optimizing Ventilation with the Open Lung Maneuver, Current Respiratory Medicine Reviews 2010; 6 (4) . https://dx.doi.org/10.2174/157339810793563686
DOI https://dx.doi.org/10.2174/157339810793563686 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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