Abstract
In the last few years, an important body of knowledge has been developed showing the pathophysiological relevance of the sublingual microcirculation in the development of multiorgan failure associated with sepsis. In addition to the compelling experimental evidence, the development of new videomicroscopic techniques allows now the evaluation of the microcirculation in critically ill patients. Consequently, the sublingual microcirculation can be easily monitored at bedside. Therefore, studies performed in the sublingual area show that severe microcirculatory sublingual alterations are present in septic patients. Moreover, these alterations have an important prognostic value. Finally, sublingual microvascular alterations can be modified by therapeutic interventions. In this article, we review relevant information related to the pathophysiology of the microcirculation in health and disease with special reference to the behavior of the mesenteric territory during shock states and the alterations of sublingual microcirculation in septic patients as well as their responses to different therapeutic approaches.
Keywords: Microcirculation, sepsis, shock, hypoxia, norepinephrine, fluids, nitroglycerin
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Microcirculatory Dysfunction in Sepsis
Volume: 10 Issue: 3
Author(s): Vanina Kanoore Edul, Gonzalo Ferrara and Arnaldo Dubin
Affiliation:
Keywords: Microcirculation, sepsis, shock, hypoxia, norepinephrine, fluids, nitroglycerin
Abstract: In the last few years, an important body of knowledge has been developed showing the pathophysiological relevance of the sublingual microcirculation in the development of multiorgan failure associated with sepsis. In addition to the compelling experimental evidence, the development of new videomicroscopic techniques allows now the evaluation of the microcirculation in critically ill patients. Consequently, the sublingual microcirculation can be easily monitored at bedside. Therefore, studies performed in the sublingual area show that severe microcirculatory sublingual alterations are present in septic patients. Moreover, these alterations have an important prognostic value. Finally, sublingual microvascular alterations can be modified by therapeutic interventions. In this article, we review relevant information related to the pathophysiology of the microcirculation in health and disease with special reference to the behavior of the mesenteric territory during shock states and the alterations of sublingual microcirculation in septic patients as well as their responses to different therapeutic approaches.
Export Options
About this article
Cite this article as:
Kanoore Edul Vanina, Ferrara Gonzalo and Dubin Arnaldo, Microcirculatory Dysfunction in Sepsis, Endocrine, Metabolic & Immune Disorders - Drug Targets 2010; 10 (3) . https://dx.doi.org/10.2174/187153010791936847
DOI https://dx.doi.org/10.2174/187153010791936847 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anti-Atherosclerotic Therapy Based on Botanicals
Recent Patents on Cardiovascular Drug Discovery Predictive In Silico Studies of Human 5-hydroxytryptamine Receptor Subtype 2B (5-HT2B) and Valvular Heart Disease
Current Topics in Medicinal Chemistry IL-1 Cytokines in Cardiovascular Disease: Diagnostic, Prognostic and Therapeutic Implications
Cardiovascular & Hematological Agents in Medicinal Chemistry Plant-based Natural Products for Wound Healing: A Critical Review
Current Drug Research Reviews β-Adrenomimetic Actions in the Hypotension and Vasodilatation Induced by a Chromatographic Active Fraction from Bidens pilosa L. (Asteraceae) in Mammals
Current Bioactive Compounds Neurogenesis and Sensorimotor Gating: Bridging a Microphenotype and an Endophenotype
Current Molecular Medicine Effect of Inhibitors of Nitric Oxide in Animal Models and Future Directions for Therapy in Inflammatory Disorders
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Induction of Cytochrome P450 3A by the Ginkgo biloba Extract and Bilobalides in Human and Rat Primary Hepatocytes
Drug Metabolism Letters Beta-Blockers use for Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry Artemisia Species as a New Candidate for Diabetes Therapy: A Comprehensive Review
Current Molecular Medicine The Role of Molecular Imaging in the Assessment of Cardiac Amyloidosis: State-of-the-Art
Current Radiopharmaceuticals Approaching Neurological Diseases to Reduce Mobility Limitations in Older Persons
Current Pharmaceutical Design The Role of Natural Killer T Cells in Acute Kidney Injury: Angel or Evil?
Current Protein & Peptide Science Safety of Inhaled Corticosteroids. Why the Variation in Systemic Adverse Effects?
Current Pediatric Reviews Organocatalyzed Heterocyclic Transformations In Green Media: A Review
Current Organocatalysis Nitrergic Modulation of Gastrointestinal Function During Early Endotoxemia
Current Pharmaceutical Design PPARγ in Angiogenesis and Vascular Development
Current Angiogenesis (Discontinued) The Role of Atypical Antipsychotic Agents in the Treatment of Schizophrenia and Schizoaffective Disorders in the Elderly
Current Drug Safety ABC Transporters, Bile Acids, and Inflammatory Stress in Liver Cancer
Current Pharmaceutical Biotechnology Tolerability of Amine Uptake Inhibitors in Urologic Diseases
Current Drug Safety