Novel Prolinamide Organocatalysts Based on Calix[4]arene Scaffold for the Enantioselective Direct Aldol Reaction

Title: Novel Prolinamide Organocatalysts Based on Calix[4]arene Scaffold for the Enantioselective Direct Aldol Reaction

Volume: 7 Issue: 6

Author(s): Zheng-Yi Li, Cheng-Xi Lu, Guoli Huang, Jie-Jie Ma, Hongsheng Sun, Leyong Wang and Yi Pan

Affiliation:

Keywords: Prolinamide, calix[4]arene, organocatalyst, asymmetric aldol reaction

Abstract: A series of novel prolinamide organocatalysts based on calix[4]arene scaffold have been developed to catalyze the direct asymmetric aldol reaction of aromatic aldehydes and cyclohexanone. Under the optimal condition, high isolated yields (up to > 99%) and enantioselectivities (up to 97% ee), and moderate diastereoselectivities (up to 85/15) were obtained.

Cite this article as:

Li Zheng-Yi, Lu Cheng-Xi, Huang Guoli, Ma Jie-Jie, Sun Hongsheng, Wang Leyong and Pan Yi, Novel Prolinamide Organocatalysts Based on Calix[4]arene Scaffold for the Enantioselective Direct Aldol Reaction, Letters in Organic Chemistry 2010; 7 (6) . https://dx.doi.org/10.2174/157017810791824919